We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440
(36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its …

This letter describes the structure–activity relationship (SAR) of the ‘right-wing’ α-amino acid
residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. Novel (S…

This letter describes the discovery of a novel series of tetrahydroisoquinoline (THIQ)-derived
small molecules that potently inhibit both human T-cell migration and super-antigen …

The ongoing evolution of SARS-CoV-2 to evade vaccines and therapeutics underlines the
need for novel therapies with high genetic barriers to resistance. The small molecule PAV-104…

Antiviral compounds displaying several remarkable features have been identified by a
uniquely enabling drug screen and advanced through validation in two animal models, and in …

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with a complex,
multifactorial pathophysiology, most commonly manifest as loss of motor neurons. We introduce a …

Polo-like kinase 1 (Plk1) is a member of the Polo-like kinase family of serine/threonine
kinases involved in the regulation of cell-cycle progression and cytokinesis and is an attractive …

Rubber band ligation (RBL) is an effective treatment for symptomatic haemorrhoids but carries
significant morbidity. We performed a prospective study of 98 consecutive patients treated …

We present a novel small molecule antiviral chemotype that was identified by an unconventional
cell-free protein synthesis and assembly-based phenotypic screen for modulation of …

Assembly modulators are a new class of allosteric site-targeted therapeutic small molecules,
some of which are effective at restoring nuclear localization of TDP-43 in ALS cellular …