In lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin
silencing, longevity, and genome stability. Here we mutated the Sirt1 gene, a homolog of yeast …

Formation of cancerous translocations requires the illegitimate joining of chromosomes
containing double-strand breaks (DSBs). It is unknown how broken chromosome ends find their …

Background Nuclear lamins are type V intermediate filament proteins that maintain nuclear
structure and function. Furthermore, Emerin - an interactor of Lamin A/C, facilitates crosstalk …

Lamin B Receptor (LBR) is an inner nuclear membrane protein that assembles the nuclear
envelope post mitosis. Here we show that LBR depletion induces mitotic defects …

Chromosomal instability (CIN) is associated with the initiation and progression of
gastrointestinal (GI) tract cancers. Cancers of the GI tract are typically characterized by altered …

Nuclear lamins are type V intermediate filament proteins that form a filamentous meshwork
beneath the inner nuclear membrane. Additionally, a sub‐population of A‐ and B‐type lamins …

Background The nuclear pore complex (NPC) mediates nuclear transport of RNA and proteins
into and out of the nucleus. Certain nucleoporins have additional functions in chromatin …

The nucleolus is required for ribosome biogenesis. Human cells have 2 or 3 nucleoli associated
with nucleolar organizer region (NOR)-bearing chromosomes. An increase in number …

The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug
targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate …

The size of amyloid seeds is known to modulate their autocatalytic amplification and cellular
toxicity. However, the seed size-dependent secondary nucleation mechanism, toxicity, and …