Mitochondria and the endoplasmic reticulum (ER) form tight structural associations and these
facilitate a number of cellular functions. However, the mechanisms by which regions of the …

Cerebral deposition of amyloid-β peptide (Aβ) within neuritic plaques is a hallmark pathology
of Alzheimer's disease. It is now generally believed that the development of this pathology …

A proline to serine substitution at position 56 in the gene encoding vesicle-associated
membrane protein-associated protein B (VAPB) causes some dominantly inherited familial forms …

Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by
death of motoneurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS …

Amyloid precursor protein (APP) is a key molecule in the pathogenesis of Alzheimer's
disease (AD) as the pathogenic amyloid-β peptide is derived from it. Two closely related APP …

The cell nucleus is a major site for polyglutamine (polyQ) toxicity, but the underlying mechanisms
involved have yet been fully elucidated. Here, we report that mutant RNAs that carry an …

Threonine 668 (thr 668 ) within the carboxy‐terminus of the Alzheimer's disease amyloid
precursor protein (APP) is a known in vivo phosphorylation site. Phosphorylation of APPthr 668 …

Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal
lobar degeneration (FTLD), the second most common cause of early-onset dementia. …

The amyloidogenic pathway leading to the production and deposition of Aβ peptides, major
constituents of Alzheimer disease senile plaques, is linked to neuronal metal homeostasis. …

Background Spinocerebellar ataxias (SCAs) are a group of clinically and genetically diverse
and autosomal-dominant disorders characterised by neurological deficits in the cerebellum. …