User profiles for Kyle J. Lampe
Kyle LampeAssistant Professor of Chemical Engineering, University of Virginia Verified email at virginia.edu Cited by 3118 |
Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers
…, W Mulyasasmita, J Su, KJ Lampe… - … Engineering Part A, 2012 - liebertpub.com
Cell transplantation is a promising therapy for a myriad of debilitating diseases; however,
current delivery protocols using direct injection result in poor cell viability. We demonstrate that …
current delivery protocols using direct injection result in poor cell viability. We demonstrate that …
Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling
Neural progenitor cell (NPC) culture within three-dimensional (3D) hydrogels is an attractive
strategy for expanding a therapeutically relevant number of stem cells. However, relatively …
strategy for expanding a therapeutically relevant number of stem cells. However, relatively …
Stimuli-responsive, pentapeptide, nanofiber hydrogel for tissue engineering
Short peptides are uniquely versatile building blocks for self-assembly. Supramolecular
peptide assemblies can be used to construct functional hydrogel biomaterials—an attractive …
peptide assemblies can be used to construct functional hydrogel biomaterials—an attractive …
Defining and designing polymers and hydrogels for neural tissue engineering
The use of biomaterials, such as hydrogels, as neural cell delivery devices is becoming more
common in areas of research such as stroke, traumatic brain injury, and spinal cord injury. …
common in areas of research such as stroke, traumatic brain injury, and spinal cord injury. …
[HTML][HTML] Design of three-dimensional engineered protein hydrogels for tailored control of neurite growth
The design of bioactive materials allows tailored studies probing cell–biomaterial interactions,
however, relatively few studies have examined the effects of ligand density and material …
however, relatively few studies have examined the effects of ligand density and material …
Tetrakis (hydroxymethyl) phosphonium chloride as a covalent cross-linking agent for cell encapsulation within protein-based hydrogels
Native tissues provide cells with complex, three-dimensional (3D) environments comprised
of hydrated networks of extracellular matrix proteins and sugars. By mimicking the …
of hydrated networks of extracellular matrix proteins and sugars. By mimicking the …
Effect of macromer weight percent on neural cell growth in 2D and 3D nondegradable PEG hydrogel culture
Neural precursor cells (NPCs) are a renewable cell source that may be useful for neural cell
transplant therapies. Their expansion and differentiation potential have traditionally been …
transplant therapies. Their expansion and differentiation potential have traditionally been …
Matrix remodeling enhances the differentiation capacity of neural progenitor cells in 3D hydrogels
Neural progenitor cells (NPCs) are a promising cell source to repair damaged nervous
tissue. However, expansion of therapeutically relevant numbers of NPCs and their efficient …
tissue. However, expansion of therapeutically relevant numbers of NPCs and their efficient …
Impact of lactic acid on cell proliferation and free radical‐induced cell death in monolayer cultures of neural precursor cells
KJ Lampe, RM Namba, TR Silverman… - Biotechnology and …, 2009 - Wiley Online Library
Biomaterials prepared from polyesters of lactic acid and glycolic acid, or a mixture of the two,
degrade in the presence of water into the naturally occurring metabolites, lactic acid and …
degrade in the presence of water into the naturally occurring metabolites, lactic acid and …
The administration of BDNF and GDNF to the brain via PLGA microparticles patterned within a degradable PEG‐based hydrogel: Protein distribution and the glial …
KJ Lampe, DS Kern, MJ Mahoney… - Journal of Biomedical …, 2011 - Wiley Online Library
Tailored delivery of neurotrophic factors (NFs) is a critical challenge that continues to inhibit
strategies for guidance of axonal growth in vivo. Of particular importance is the ability to …
strategies for guidance of axonal growth in vivo. Of particular importance is the ability to …