Piezo channels transduce mechanical stimuli into electrical and chemical signals to powerfully
influence development, tissue homeostasis, and regeneration. Studies on Piezo1 have …

Local Ca 2+ transients such as puffs and sparks form the building blocks of cellular Ca 2+
signaling in numerous cell types. They have traditionally been studied by linescan confocal …

The range of action of intracellular messengers is determined by their rates of diffusion and
degradation. Previous measurements in oocyte cytoplasmic extracts indicated that the Ca 2+ …

Total internal reflection fluorescence (TIRF) microscopy is a powerful tool for visualizing near-membrane
cellular structures and processes, including imaging of local Ca 2+ transients …

Skeletal muscle injury provokes a regenerative response, characterized by the de novo
generation of myofibers that are distinguished by central nucleation and re-expression of …

We describe the construction of a simplified, inexpensive lattice light-sheet microscope, and
illustrate its use for imaging subcellular Ca 2+ puffs evoked by photoreleased i-IP 3 in …

Connexin‐36 (Cx36) gap junctions (GJs) appear to be involved in the synchronization of
GABA interneurons in many brain areas. We have previously identified a population of Cx36‐…

The patterning of cytosolic Ca 2+ signals underlies their ubiquitous ability to specifically
regulate numerous cellular processes. Advances in fluorescence microscopy have made it …

Cytosolic Ca2+ ions regulate numerous aspects of cellular activity in almost all cell types,
controlling processes as wide-ranging as gene transcription, electrical excitability and cell …

The maturation of cortical parvalbumin-positive (PV) interneurons depends on the interaction
of innate and experience-dependent factors. Dark-rearing experiments suggest that visual …