Protein aggregation results in β-sheet–like assemblies that adopt either a variety of amorphous
morphologies or ordered amyloid-like structures. These differences in structure also …

Amyloid fibril deposition is central to the pathology of more than 30 unrelated diseases
including Alzheimer's disease and Type 2 diabetes. It is generally accepted that amyloid fibrils …

The β-amyloid peptide (Aβ) is directly related to neurotoxicity in Alzheimer disease (AD). The
two most abundant alloforms of the peptide co-exist under normal physiological conditions …

Controlling the order and spatial distribution of self-assembly in multicomponent supramolecular
systems could underpin exciting new functional materials, but it is extremely challenging…

Amyloid-like fibrous crystals formed by the peptide KFFEAAAKKFFE have been previously
characterized and provide an ideal model system to examine the importance of specific …

Background Alzheimer’s disease (AD) is characterized by the deposition of insoluble amyloid
plaques in the neuropil composed of highly stable, self-assembled Amyloid-beta (Aβ) fibrils…

Naphthalene dipeptides have been shown to be useful low-molecular-weight gelators. Here
we have used a library to explore the relationship between the dipeptide sequence and the …

Amyloid fibrils are polymeric assemblies of normally soluble proteins or peptides. To
investigate their structure, it is generally not possible to use conventional methods of …

Self-sorting in low molecular weight hydrogels can be achieved using a pH triggered
approach. We show here that this method can be used to prepare gels with different types of …

A number of Fmoc amino acids can be effective low molecular weight hydrogelators. The
type of gel formed depends on the amino acid used and, in the case of FmocF, the final pH of …