Multiple reaction monitoring (MRM) mass spectrometry has been successfully applied to
monitor targeted proteins in biological specimens, raising the possibility that assays could be …

With the prospect of resolving whole protein molecules into their myriad proteoforms on a
proteomic scale, the question of their quantitative analysis in discovery mode comes to the fore…

Reduced amino acid availability attenuates mRNA translation in cells and helps to extend
lifespan in model organisms. The amino acid deprivation–activated kinase GCN2 mediates …

Embryonic stem cell (ESC) abnormalities in genome methylation hamper the utility of their
therapeutic derivatives; however, the underlying mechanisms are unknown. Here, we show …

Diabetes can lead to serious microvascular complications like proliferative diabetic retinopathy
(PDR), which is the leading cause of blindness in adults. The proteomic changes that …

Genetic mutations in BRCA1, which is crucial for the process of DNA repair and maintenance
of genomic integrity, are known to increase markedly the risk of breast and ovarian cancers…

Background Brain-derived exosomes released into the blood are considered a liquid biopsy
to investigate the pathophysiological state, reflecting the aberrant heterogeneous pathways …

Molecular programs involved in embryogenesis are frequently upregulated in oncogenic
dedifferentiation and metastasis. However, their precise roles and regulatory mechanisms …

5-Methylcytosine (5mC) oxidases, the ten-eleven translocation (TET) proteins, initiate DNA
demethylation, but it is unclear how 5mC oxidation is regulated. We show that the protein …

Renal dysfunction, a major complication of type 2 diabetes, can be predicted from estimated
glomerular filtration rate (eGFR) and protein markers such as albumin concentration. …