We have been developing new inhibitors for c-Jun N-terminal kinase 3 (JNK3) as a potential
treatment for Alzheimer’s disease (AD). We identified potential JNK3 inhibitors through …

Despite innumerable efforts to develop effective therapeutics, it is difficult to achieve breakthrough
treatments for Alzheimer's disease (AD), and the main reason is probably the absence …

Pellino-1 is an E3 ubiquitin ligase acting as a critical mediator for a variety of immune
receptor signaling pathways, including Toll-like receptors, interleukin-1 receptor and T-cell …

Psoriasis is one of the most common immune-mediated chronic inflammatory skin diseases.
However, little is known about the molecular mechanism underlying the immunological …

Chronic skin inflammation including psoriasis is a multisystem disease, affecting more than
5% of the general population. Here we show that Pellino 1 (Peli1), a signal-responsive …

Background: There is strong evidence of a downward secular trend in age at menarche in
Europe and the USA during the last century and in Japan and China during the past few …

Purpose We aimed to reveal the prognostic influence of B-cell CLL/lymphoma 2 (BCL2) on
molecular subtypes of breast cancer. Methods We analyzed 9,468 patients with primary …

This multicenter retrospective cohort study compared the effectiveness and safety of long-term
tafluprost, travoprost, or latanoprost in patients with primary open-angle glaucoma (POAG) …

Purpose.: We evaluated the clinical use of segmented macular layer thickness measurement
in terms of glaucoma diagnosis and the ability to detect progression, and to compare such …

… Park, Jae-Eup;Lee, In-Yong;Oh, Se-Mun;Park, Tae-Sun;Kim, Chang-Seog;Moon, Byeong-Chul;Cho,
Jeong-Rae;Lim, Soon-Taek;Im, Il-Bin;Kang, Jong-Gook;Kim, Sun;Hwang, Jae-Bok;Song …