Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

…, A Kawalia, S Li, RM Huebinger, L Kilander… - Nature …, 2019 - nature.com
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men

L Kilander, H Nyman, M Boberg, L Hansson… - Hypertension, 1998 - Am Heart Assoc
… Lena Kilander … Plasma glucose was significantly higher in nondippers (6.3 mmol/L)
than in dippers (5.7 mmol/L), independent of 24-hour DBP (P=.008, logistic regression). …

Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study

B Winblad, L Kilander, S Eriksson, L Minthon… - The Lancet, 2006 - thelancet.com
L Kilander has received honoraria from Pfizer to speak at meetings and is on their advisory
board. S Båtsman has taken part in advisory board meetings of Pfizer and Lundbeck and has …

Impaired insulin secretion increases the risk of Alzheimer disease

…, C Berne, L Lannfelt, L Kilander - Neurology, 2008 - AAN Enterprises
Objective: Subjects with diabetes are reported to have an increased risk of dementia and
cognitive impairment. However, the underlying causes remain unknown. We investigated the …

Prevalence estimates of amyloid abnormality across the Alzheimer disease clinical spectrum

…, R Kandimalla, EN Kapaki, S Kern, L Kilander… - JAMA …, 2022 - jamanetwork.com
Importance One characteristic histopathological event in Alzheimer disease (AD) is cerebral
amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and …

Atrial fibrillation is an independent determinant of low cognitive function: a cross-sectional study in elderly men

L Kilander, B Andrén, H Nyman, L Lind, M Boberg… - Stroke, 1998 - Am Heart Assoc
Background and Purpose—Cerebrovascular disease is increasingly recognized as a cause
of dementia and cognitive decline. We have previously reported an association between …

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival

…, C Rosén, N Mattsson, K Nägga, L Kilander… - Neurology, 2014 - AAN Enterprises
… of detection of 250 ng/L, 24 which was later improved to 125 ng/L. The third method was
a … ), with a limit of detection of 50 ng/L. The third method produces highly correlated results, …

Determinants of costs of care for patients with Alzheimer's disease

L Jönsson, ME Jönhagen, L Kilander… - … Journal of Geriatric …, 2006 - Wiley Online Library
Background Alzheimer's disease (AD), the most common cause of dementia, is a major cause
of disability and care burden in the elderly. This study aims to estimate the costs of formal …

Education, lifestyle factors and mortality from cardiovascular disease and cancer. A 25-year follow-up of Swedish 50-year-old men

L Kilander, L Berglund, M Boberg… - International journal …, 2001 - academic.oup.com
… Lipid-adjusted alpha tocopherol, calculated as the quotient between alpha tocopherol (mmol/l)
and the sum of serum total cholesterol and triglycerides (mmol/l), was used in the …

[PDF][PDF] Mosaic loss of chromosome Y in blood is associated with Alzheimer disease

…, L Lannfelt, M Ingelsson, L Kilander, L Lind… - The American Journal of …, 2016 - cell.com
Men have a shorter life expectancy compared with women but the underlying factor(s) are
not clear. Late-onset, sporadic Alzheimer disease (AD) is a common and lethal …