Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
…, A Kawalia, S Li, RM Huebinger, L Kilander… - Nature …, 2019 - nature.com
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …
Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men
L Kilander, H Nyman, M Boberg, L Hansson… - Hypertension, 1998 - Am Heart Assoc
… Lena Kilander … Plasma glucose was significantly higher in nondippers (6.3 mmol/L)
than in dippers (5.7 mmol/L), independent of 24-hour DBP (P=.008, logistic regression). …
than in dippers (5.7 mmol/L), independent of 24-hour DBP (P=.008, logistic regression). …
Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study
B Winblad, L Kilander, S Eriksson, L Minthon… - The Lancet, 2006 - thelancet.com
… L Kilander has received honoraria from Pfizer to speak at meetings and is on their advisory
board. S Båtsman has taken part in advisory board meetings of Pfizer and Lundbeck and has …
board. S Båtsman has taken part in advisory board meetings of Pfizer and Lundbeck and has …
Impaired insulin secretion increases the risk of Alzheimer disease
…, C Berne, L Lannfelt, L Kilander - Neurology, 2008 - AAN Enterprises
Objective: Subjects with diabetes are reported to have an increased risk of dementia and
cognitive impairment. However, the underlying causes remain unknown. We investigated the …
cognitive impairment. However, the underlying causes remain unknown. We investigated the …
Prevalence estimates of amyloid abnormality across the Alzheimer disease clinical spectrum
Importance One characteristic histopathological event in Alzheimer disease (AD) is cerebral
amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and …
amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and …
Atrial fibrillation is an independent determinant of low cognitive function: a cross-sectional study in elderly men
L Kilander, B Andrén, H Nyman, L Lind, M Boberg… - Stroke, 1998 - Am Heart Assoc
Background and Purpose—Cerebrovascular disease is increasingly recognized as a cause
of dementia and cognitive decline. We have previously reported an association between …
of dementia and cognitive decline. We have previously reported an association between …
CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival
…, C Rosén, N Mattsson, K Nägga, L Kilander… - Neurology, 2014 - AAN Enterprises
… of detection of 250 ng/L, 24 which was later improved to 125 ng/L. The third method was
a … ), with a limit of detection of 50 ng/L. The third method produces highly correlated results, …
a … ), with a limit of detection of 50 ng/L. The third method produces highly correlated results, …
Determinants of costs of care for patients with Alzheimer's disease
L Jönsson, ME Jönhagen, L Kilander… - … Journal of Geriatric …, 2006 - Wiley Online Library
Background Alzheimer's disease (AD), the most common cause of dementia, is a major cause
of disability and care burden in the elderly. This study aims to estimate the costs of formal …
of disability and care burden in the elderly. This study aims to estimate the costs of formal …
Education, lifestyle factors and mortality from cardiovascular disease and cancer. A 25-year follow-up of Swedish 50-year-old men
L Kilander, L Berglund, M Boberg… - International journal …, 2001 - academic.oup.com
… Lipid-adjusted alpha tocopherol, calculated as the quotient between alpha tocopherol (mmol/l)
and the sum of serum total cholesterol and triglycerides (mmol/l), was used in the …
and the sum of serum total cholesterol and triglycerides (mmol/l), was used in the …
[PDF][PDF] Mosaic loss of chromosome Y in blood is associated with Alzheimer disease
…, L Lannfelt, M Ingelsson, L Kilander, L Lind… - The American Journal of …, 2016 - cell.com
Men have a shorter life expectancy compared with women but the underlying factor(s) are
not clear. Late-onset, sporadic Alzheimer disease (AD) is a common and lethal …
not clear. Late-onset, sporadic Alzheimer disease (AD) is a common and lethal …