We have not yet reached a point at which routine sequencing of large numbers of whole
eukaryotic genomes is feasible, and so it is often necessary to select genomic regions of interest …

Despite their crucial role in health and disease, our knowledge of immune cells within human
tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult …

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…

It is not fully understood why COVID-19 is typically milder in children 1 , 2 – 3 . Here, to examine
the differences between children and adults in their response to SARS-CoV-2 infection, …

The cellular landscape of the human intestinal tract is dynamic throughout life, developing
in utero and changing in response to functional requirements and environmental exposures. …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor (TCR)
repertoire formation, which shapes the landscape of adaptive immunity. T cell …

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in …

Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it
defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 …

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re)define tissue architecture of …