The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug
resistance in clinical samples, and improvements in global surveillance. Here we show how …

Background Slow and cumbersome laboratory diagnostics for Mycobacterium tuberculosis
complex (MTBC) risk delayed treatment and poor patient outcomes. Whole-genome …

Escherichia coli sequence type 131 (ST131) has emerged globally as the most predominant
extraintestinal pathogenic lineage within this clinically important species, and its …

Routine full characterization of Mycobacterium tuberculosis is culture based, taking many
weeks. Whole-genome sequencing (WGS) can generate antibiotic susceptibility profiles to …

The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a
major public health concern, as carbapenems are a therapy of last resort against this family of …

Background Low fibrinogen (Fg) concentrations in trauma haemorrhage are associated with
poorer outcomes. Cryoprecipitate is the standard source for Fg administration in the UK and …

The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We studied …

Quantitative evidence for the risk of zoonoses and the spread of antimicrobial resistance
remains lacking. Here, as part of the UrbanZoo project, we sampled Escherichia coli from …

The global emergence of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae
(KPC-Kp) multilocus sequence type ST258 is widely recognized. Less is known about the …

Carbapenem-resistant Enterobacteriaceae (CRE) represent a health threat, but effective
control interventions remain unclear. Hospital wastewater sites are increasingly being …