Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…

… Neuroimaging features included atrophy in both parietal regions (R>L) and SPECT
revealed hypoperfusion in temporoparietal regions (R>L). This variant alters a non-conserved …

Background In order to identify novel loci associated with Alzheimer's disease (AD), we
conducted a genome-wide association study (GWAS) in the Spanish population. Methods We …

Background The Neuropsychiatric Inventory (NPI) is a validated clinical instrument for the
evaluation of psychopathology in dementia. Objective To validate a brief questionnaire form of …

A clinical investigation program was carried out to replace endogenous albumin of patients
with mild to moderate Alzheimer's disease (AD) with 5% Human Albumin Grifols (R) through …

Methods: In a multicenter, randomized, patient-and rater-blind, controlled, parallel-group,
phase II study, 42 AD patients were assigned (1: 1) to PE treatment or control (sham) groups. …

Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent
in Alzheimer disease (AD), affecting~ 40 to 60% of individuals with AD (AD with psychosis (…

Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent
in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD…

The use of optical coherence tomography (OCT) has been suggested as a potential biomarker
for Alzheimer’s Disease based on previously reported thinning of the retinal nerve fiber …