User profiles for L. A. Clifton
Luke A CliftonISIS Pulsed Neutron and Muon Source Verified email at stfc.ac.uk Cited by 2803 |
Design and use of model membranes to study biomolecular interactions using complementary surface-sensitive techniques
LA Clifton, RA Campbell, F Sebastiani… - Advances in colloid and …, 2020 - Elsevier
Cellular membranes are complex structures and simplified analogues in the form of model
membranes or biomembranes are used as platforms to understand fundamental properties of …
membranes or biomembranes are used as platforms to understand fundamental properties of …
Effect of divalent cation removal on the structure of gram-negative bacterial outer membrane models
LA Clifton, MWA Skoda, AP Le Brun, F Ciesielski… - Langmuir, 2015 - ACS Publications
The Gram-negative bacterial outer membrane (GNB-OM) is asymmetric in its lipid composition
with a phospholipid-rich inner leaflet and an outer leaflet predominantly composed of …
with a phospholipid-rich inner leaflet and an outer leaflet predominantly composed of …
Asymmetric phospholipid: lipopolysaccharide bilayers; a Gram-negative bacterial outer membrane mimic
LA Clifton, MWA Skoda, EL Daulton… - Journal of the …, 2013 - royalsocietypublishing.org
The Gram-negative bacterial outer membrane (OM) is a complex and highly asymmetric
biological barrier but the small size of bacteria has hindered advances in in vivo examination of …
biological barrier but the small size of bacteria has hindered advances in in vivo examination of …
An Accurate In Vitro Model of the E. coli Envelope
LA Clifton, SA Holt, AV Hughes… - Angewandte Chemie …, 2015 - Wiley Online Library
Gram‐negative bacteria are an increasingly serious source of antibiotic‐resistant infections,
partly owing to their characteristic protective envelope. This complex, 20 nm thick barrier …
partly owing to their characteristic protective envelope. This complex, 20 nm thick barrier …
Self-assembly of peptide nanotubes in an organic solvent
The self-assembly of a modified fragment of the amyloid β peptide, based on sequence Aβ(16−20),
KLVFF, extended to give AAKLVFF is studied in methanol. Self-assembly into …
KLVFF, extended to give AAKLVFF is studied in methanol. Self-assembly into …
Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system
The Mla pathway is believed to be involved in maintaining the asymmetrical Gram-negative
outer membrane via retrograde phospholipid transport. The pathway is composed of three …
outer membrane via retrograde phospholipid transport. The pathway is composed of three …
Structural Characterization of a Model Gram-Negative Bacterial Surface Using Lipopolysaccharides from Rough Strains of Escherichia coli
AP Le Brun, LA Clifton, CE Halbert, B Lin… - …, 2013 - ACS Publications
Lipopolysaccharides (LPS) make up approximately 75% of the Gram-negative bacterial outer
membrane (OM) surface, but because of the complexity of the molecule, there are very few …
membrane (OM) surface, but because of the complexity of the molecule, there are very few …
The effect of lipopolysaccharide core oligosaccharide size on the electrostatic binding of antimicrobial proteins to models of the gram negative bacterial outer …
Understanding the electrostatic interactions between bacterial membranes and exogenous
proteins is crucial to designing effective antimicrobial agents against Gram-negative bacteria. …
proteins is crucial to designing effective antimicrobial agents against Gram-negative bacteria. …
Structural investigations of protein–lipid complexes using neutron scattering
Neutron scattering has significant benefits for examining the structure of protein–lipid
complexes. Cold (slow) neutrons are nondamaging and predominantly interact with the atomic …
complexes. Cold (slow) neutrons are nondamaging and predominantly interact with the atomic …
Structural disruptions of the outer membranes of gram-negative bacteria by rationally designed amphiphilic antimicrobial peptides
Gram-negative bacteria are covered by both an inner cytoplasmic membrane (IM) and an
outer membrane (OM). Antimicrobial peptides (AMPs) must first permeate through the OM and …
outer membrane (OM). Antimicrobial peptides (AMPs) must first permeate through the OM and …