User profiles for L. A. Clifton

Luke A Clifton

ISIS Pulsed Neutron and Muon Source
Verified email at stfc.ac.uk
Cited by 2803

Design and use of model membranes to study biomolecular interactions using complementary surface-sensitive techniques

LA Clifton, RA Campbell, F Sebastiani… - Advances in colloid and …, 2020 - Elsevier
Cellular membranes are complex structures and simplified analogues in the form of model
membranes or biomembranes are used as platforms to understand fundamental properties of …

Effect of divalent cation removal on the structure of gram-negative bacterial outer membrane models

LA Clifton, MWA Skoda, AP Le Brun, F Ciesielski… - Langmuir, 2015 - ACS Publications
The Gram-negative bacterial outer membrane (GNB-OM) is asymmetric in its lipid composition
with a phospholipid-rich inner leaflet and an outer leaflet predominantly composed of …

Asymmetric phospholipid: lipopolysaccharide bilayers; a Gram-negative bacterial outer membrane mimic

LA Clifton, MWA Skoda, EL Daulton… - Journal of the …, 2013 - royalsocietypublishing.org
The Gram-negative bacterial outer membrane (OM) is a complex and highly asymmetric
biological barrier but the small size of bacteria has hindered advances in in vivo examination of …

An Accurate In Vitro Model of the E. coli Envelope

LA Clifton, SA Holt, AV Hughes… - Angewandte Chemie …, 2015 - Wiley Online Library
Gram‐negative bacteria are an increasingly serious source of antibiotic‐resistant infections,
partly owing to their characteristic protective envelope. This complex, 20 nm thick barrier …

Self-assembly of peptide nanotubes in an organic solvent

MJ Krysmann, V Castelletto, JE McKendrick, LA Clifton… - Langmuir, 2008 - ACS Publications
The self-assembly of a modified fragment of the amyloid β peptide, based on sequence Aβ(16−20),
KLVFF, extended to give AAKLVFF is studied in methanol. Self-assembly into …

Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system

…, M Jeeves, D Huber, IR Henderson, LA Clifton… - Nature …, 2019 - nature.com
The Mla pathway is believed to be involved in maintaining the asymmetrical Gram-negative
outer membrane via retrograde phospholipid transport. The pathway is composed of three …

Structural Characterization of a Model Gram-Negative Bacterial Surface Using Lipopolysaccharides from Rough Strains of Escherichia coli

AP Le Brun, LA Clifton, CE Halbert, B Lin… - …, 2013 - ACS Publications
Lipopolysaccharides (LPS) make up approximately 75% of the Gram-negative bacterial outer
membrane (OM) surface, but because of the complexity of the molecule, there are very few …

The effect of lipopolysaccharide core oligosaccharide size on the electrostatic binding of antimicrobial proteins to models of the gram negative bacterial outer …

LA Clifton, F Ciesielski, MWA Skoda, N Paracini… - Langmuir, 2016 - ACS Publications
Understanding the electrostatic interactions between bacterial membranes and exogenous
proteins is crucial to designing effective antimicrobial agents against Gram-negative bacteria. …

Structural investigations of protein–lipid complexes using neutron scattering

LA Clifton, SCL Hall, N Mahmoudi, TJ Knowles… - … : Methods and Protocols, 2019 - Springer
Neutron scattering has significant benefits for examining the structure of protein–lipid
complexes. Cold (slow) neutrons are nondamaging and predominantly interact with the atomic …

Structural disruptions of the outer membranes of gram-negative bacteria by rationally designed amphiphilic antimicrobial peptides

…, X Hu, M Liao, K Fa, D Ciumac, LA Clifton… - … applied materials & …, 2021 - ACS Publications
Gram-negative bacteria are covered by both an inner cytoplasmic membrane (IM) and an
outer membrane (OM). Antimicrobial peptides (AMPs) must first permeate through the OM and …