5676 kinases induced by ligands (such as insulin or other growth factors),(2) stimulation of G-protein-coupled
receptors, or (3) activation of integrin signalling (Foster et al., 2003; …

The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic motor …

Cellular homeostasis depends upon the strict regulation of responses to external stimuli,
such as signalling cascades triggered by nutrients and growth factors, and upon cellular …

MyoD controls myoblast identity and differentiation and is required for myogenic stem cell
function in adult skeletal muscle. MyoD is degraded by the ubiquitin-proteasome pathway …

… Miss J Lagirand-Cantaloube held a graduate fellowship from the ‘Ministère de la Recherche
et de la Technologie’ (MRT) and an AFM fellowship. Mrs A Csibi holds a graduate AFM …

Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated
in a growing number of myopathological conditions. Although FoxO3 was shown to …

With human median lifespan extending into the 80s in many developed countries, the societal
burden of age-related muscle loss (sarcopenia) is increasing. mTORC1 promotes skeletal …

Background Skeletal muscle mass is determined by the balance between protein synthesis
and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator …

The mTORC1 pathway is required for both the terminal muscle differentiation and hypertrophy
by controlling the mammalian translational machinery via phosphorylation of S6K1 and 4E…

Syncytia arising from the fusion of cells expressing the HIV-1-encoded Env gene with cells
expressing the CD4/CXCR4 complex undergo apoptosis following the nuclear translocation …