Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has fueled
remarkable advances in our understanding of its potential neurobiological mechanisms. …

… We overlapped gene coordinates from Gencode v.19 with LD regions as defined in the
original study 22 to find genes that reside in LD regions. The closest genes and LD genes were …

… (LD) score regression to partition disease heritability within functional categories represented
by gene co-expression modules 41 . This method uses GWAS summary statistics and LD …

We performed RNA sequencing on 40,000 cells to create a high-resolution single-cell gene
expression atlas of developing human cortex, providing the first single-cell characterization …

Non-coding regions comprise most of the human genome and harbor a significant fraction
of risk alleles for neuropsychiatric diseases, yet their functions remain poorly defined. We …

Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …

Histone methylation regulates chromatin structure and transcription. The recently identified
histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to …

… Immunohistochemistry on coronal brain sections from 2.5-mo-old FoxO6 mutant and wild-…
(2 mo of age) but then stayed relatively constant through old age (24 mo of age) (Fig. 1B,C). …

… the index e/sSNPs were in LD (r2 > 0.8 where LD was calculated in our sample population)
… found within LD buddies of cell-type-specific e/sQTLs at LD r2 > 0.8 (where LD is calculated …

… We found that the most significant caSNP or an LD-proxy was located in annotated
functional regions for over 80% of caPeaks (Fig. 2c and Supplementary Table 3). These results …