Endoglin is a transforming growth factor–β (TGF-β) binding protein expressed on the surface
of endothelial cells. Loss-of-function mutations in the human endoglin gene ENGcause …

The mature circulatory system is comprised of two parallel, yet distinct, vascular networks
that carry blood to and from the heart. Studies have suggested that endothelial tubes are …

Background Conditional knockout mice and transgenic mice expressing recombinases,
reporters, and inducible transcriptional activators are key for many genetic studies and comprise …

Axonal guidance and vascular patterning share several guidance cues, including proteins
in the netrin family. We demonstrate that netrins stimulate proliferation, migration, and tube …

Guidance and patterning of axons are orchestrated by cell-surface receptors and ligands that
provide directional cues. Interactions between the Robo receptor and Slit ligand families of …

Several characteristic morphological and functional differences distinguish arteries from
veins. It was thought that hemodynamic forces shaped these differences; however, increasing …

Using differential display of rat fetal and postnatal cardiomyocytes, we have identified a novel
seven-transmembrane receptor, ETL. The cDNA-predicted amino acid sequence of ETL …

The inner ear epithelium, with its complex array of sensory, non-sensory, and neuronal cell
types necessary for hearing and balance, is derived from a thickened patch of head ectoderm …

The E74 early ecdysone-Inducible gene plays a key role in the regulatory hierarchy activated
by ecdysone at the onset of Drosophila metamorphosis. We show here that E74A proteln …

… 1Sms ; MGI:3526181; each abbreviated “Δ2” or “–”), the Hprt Cre allele (Hprt tm1(cre)Mnn
; MGI:2181632), and genotyping protocols used in this study are described in Urness et al. (…