User profiles for L. E. Colbert

Lauren Colbert

MD Anderson Cancer Center
Verified email at mdanderson.org
Cited by 1350

[HTML][HTML] Microbiome factors in HPV-driven carcinogenesis and cancers

…, AH Klopp, CM Taniguchi, LE Colbert - PLos …, 2020 - journals.plos.org
Human papillomavirus (HPV) infections account for over 600,000 new cancer cases every
year [1]. HPV is implicated in approximately 70% of oropharyngeal cancers (OPCs), 90% of …

Pronecrotic mixed lineage kinase domain‐like protein expression is a prognostic biomarker in patients with early‐stage resected pancreatic adenocarcinoma

LE Colbert, SB Fisher, CW Hardy, WA Hall, B Saka… - Cancer, 2013 - Wiley Online Library
BACKGROUND Mixed lineage kinase domain‐like protein (MLKL) is a necrosome component
mediating programmed necrosis that may be an important determinant of cancer cell …

[HTML][HTML] Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation

…, KM Schmeler, NJ Ajami, J Wargo, LE Colbert… - Communications …, 2021 - nature.com
Diversity of the gut microbiome is associated with higher response rates for cancer patients
receiving immunotherapy but has not been investigated in patients receiving radiation …

[PDF][PDF] Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring

LE Colbert, MB El Alam, R Wang, T Karpinets, D Lo… - Cancer cell, 2023 - cell.com
Tumor microbiota can produce active metabolites that affect cancer and immune cell signaling,
metabolism, and proliferation. Here, we explore tumor and gut microbiome features that …

Brachytherapy training survey of radiation oncology residents

SR Marcrom, JM Kahn, LE Colbert, CM Freese… - International Journal of …, 2019 - Elsevier
Purpose As brachytherapy utilization rates decline, we sought to evaluate the state of
brachytherapy training during radiation oncology residency. Methods and Materials US radiation …

Gut microbial diversity and genus-level differences identified in cervical cancer patients versus healthy controls

TT Sims, LE Colbert, J Zheng, AYD Medrano… - Gynecologic …, 2019 - Elsevier
Objectives The aim of this study was to characterize variation in the gut microbiome of women
with locally advanced cervical cancer and compare it to healthy controls. Methods We …

Biology of the radio-and chemo-responsiveness in HPV malignancies

MT Spiotto, CM Taniguchi, AH Klopp, LE Colbert… - Seminars in radiation …, 2021 - Elsevier
In multiple anatomic sites, patients with cancers associated with the Human Papillomavirus (HPV)
experience better locoregional control and overall survival after radiotherapy and/or …

Proton beam radiation as salvage therapy for bilateral colorectal liver metastases not amenable to second-stage hepatectomy

LE Colbert, JM Cloyd, EJ Koay, CH Crane, JN Vauthey - Surgery, 2017 - Elsevier
Background Bilobar colorectal liver metastases (CRLM), are now aggressively managed in
a multidisciplinary fashion with a two-stage hepatectomy; however, up to 30% of patients are …

Microbial diversity and composition is associated with patient-reported toxicity during chemoradiation therapy for cervical cancer

…, TT Sims, K Schmeler, P Okhuysen, LE Colbert… - International Journal of …, 2020 - Elsevier
Purpose Patients receiving pelvic radiation for cervical cancer experience high rates of acute
gastrointestinal (GI) toxicity. The association of changes in the gut microbiome with bowel …

CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer

LE Colbert, AV Petrova, SB Fisher, BG Pantazides… - Cancer research, 2014 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor outcomes
with current therapies. Gemcitabine is the primary adjuvant drug used clinically, but its …