Aim: Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing
– including scarring. The aim here was to study the effects of a cell-permeant peptide from …

A major limitation in studies of the injured heart is animal-to-animal variability in wound size
resulting from commonly used techniques such as left anterior descending coronary artery …

The intercalated disc (ICD) is a unique membrane structure that is indispensable to normal
heart function, yet its structural organization is not completely understood. Previously, we …

… Jane Jourdan … Jane Jourdan … Dr Gourdie and LJ Jourdan have modest (<3% of total
stock) ownership interests in the company. The remaining authors have no disclosures to report. …

Phase II clinical trials have reported that acute treatment of surgical skin wounds with the
therapeutic peptide αCT1 improves cutaneous scar appearance by 47% nine-months post-…

Treatment of cardiac arrhythmias by targeting ion channels is challenging, with safe and
effective therapies remaining an unmet clinical need. Modeling and experimental studies have …

Phase II clinical trials have reported that acute treatment of surgical skin wounds with the
therapeutic peptide αCT1 improves cutaneous scar appearance by 47% 9-months post-surgery …

Background αCT1 is a 25 amino acid therapeutic peptide incorporating the Zonula Occludens-1
(ZO-1)-binding domain of connexin43 (Cx43) that is currently in Phase III clinical testing …

Cardiac ischemia-reperfusion (IR) injury occurs in patients with acute coronary syndromes
undergoing percutaneous intervention to re-establish blood flow in blocked or narrowed …

Coastal and estuarine ecosystems are environments heavily influenced by natural and
anthropogenic activities. Chemicals used for pest control in agriculture and aquaculture may …