DNA curvature and flexibility in vitro and in vivo

JP Peters, LJ Maher - Quarterly reviews of biophysics, 2010 - cambridge.org
It has been more than 50 years since the elucidation of the structure of double-helical DNA.
Despite active research and progress in DNA biology and biochemistry, much remains to be …

Having it both ways: transcription factors that bind DNA and RNA

LA Cassiday, LJ Maher III - Nucleic acids research, 2002 - academic.oup.com
LJMaher III, unpublished results). Such RNA optimization may reflect improved in vivo binding
affinity, or selection for other parameters such as RNA accumulation, localization, folding …

DNA triple‐helix formation: An approach to artificial gene repressors?

LJ Maher III - BioEssays, 1992 - Wiley Online Library
Certain sequences of double‐helical DNA can be recognized and tightly bound by
oligonucleotides. The effects of such triple‐helical structures on DNA binding proteins have been …

Statistics for microfossil concentration measurements employing samples spiked with marker grains

LJ Maher Jr - Review of Palaeobotany and Palynology, 1981 - Elsevier
Microfossil abundance in sediment is often expressed as the proportion each taxon comprises
in the total assemblage. A different way to calculate abundance involves adding a known …

Precipitating electron energy flux and auroral zone conductances‐An empirical model

RW Spiro, PH Reiff, LJ Maher Jr - Journal of Geophysical …, 1982 - Wiley Online Library
Data from the low energy electron (LEE) experiments on the Atmosphere Explorer C and D
satellites have been used to determine the average global distribution of the energy flux of …

Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation

LJ Maher III, B Wold, PB Dervan - Science, 1989 - science.org
Oligonucleotides that bind to duplex DNA in a sequence-specific manner by triple helix
formation offer an approach to the experimental manipulation of sequence-specific protein …

Nomograms for computing 0.95 confidence limits of pollen data

LJ Maher Jr - Review of Palaeobotany and Palynology, 1972 - Elsevier
Confidence limits should be displayed on pollen diagrams to aid in their interpretation.
Mosimann (1965) has provided complex but useful equations to estimate 0.95 confidence limits …

Succinate inhibition of α-ketoglutarate-dependent enzymes in a yeast model of paraganglioma

…, R Janknecht, LJ Maher III - Human molecular …, 2007 - academic.oup.com
The tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase (SDH) is a tumor
suppressor. Heterozygosity for defective SDH subunit genes predisposes to familial …

Crystal structure of NF-κB (p50)2 complexed to a high-affinity RNA aptamer

…, JM Zimmerman, LJ Maher III… - Proceedings of the …, 2003 - National Acad Sciences
We have recently identified an RNA aptamer for the transcription factor NF-κB p50 homodimer
[(p50) 2 ], which exhibits little sequence resemblance to the consensus DNA target for (p50…

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

…, P Bielecki, O Khan, R Jackson, Y Kluger, LJ Maher III… - Nature, 2019 - nature.com
Activated CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell
cycle and engaging acquired effector functions. Metabolic reprogramming from the naive state …