How diversity evolves and persists in biofilms is essential for understanding much of microbial
life, including the uncertain dynamics of chronic infections. We developed a biofilm model …

We characterized the acute B cell response in adults with cholera by analyzing the repertoire,
specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) generated …

Vibrio cholerae O1 is a major cause of acute watery diarrhea in over 50 countries. Evidence
suggests that V. cholerae O1 may activate inflammatory pathways, and a recent study of a …

The mechanism of protection against cholera afforded by previous illness or vaccination is
currently unknown. We have recently shown that antibodies targeting O-specific …

Background Studies of the immunogenicity of the killed bivalent whole cell oral cholera
vaccine, Shanchol, have been performed in historically cholera-endemic areas of Asia. There is …

Cholera is a severe, water-borne diarrhoeal disease caused by toxin-producing strains of
the bacterium Vibrio cholerae. Comparative genomics has revealed ‘waves’ of cholera …

Background Cholera is an acute voluminous dehydrating diarrheal disease caused by
toxigenic strains of Vibrio cholerae O1 and occasionally O139. A growing body of evidence …

To better understand the innate immune response to Vibrio cholerae infection, we tracked
gene expression in the duodenal mucosa of 11 Bangladeshi adults with cholera, using biopsy …

One potential advantage of live attenuated bacterial vaccines is the ability to stimulate
responses to antigens which are only expressed during the course of infection. To determine …

Background Antibodies targeting O-specific polysaccharide (OSP) of Vibrio cholerae may
protect against cholera; however, little is known about this immune response in infected …