User profiles for L. S. Weinberger
 | Leor WeinbergerUCSF Verified email at gladstone.ucsf.edu Cited by 6706 |
Stochastic gene expression as a molecular switch for viral latency
A Singh, LS Weinberger - Current opinion in microbiology, 2009 - Elsevier
… We thank Mike Simpson, Cynthia Bolovan-Fritts, Winnie Wen, Melissa Wong, Brandon
Razooky, and members of the Weinberger laboratory for helpful discussions. LSW acknowledges …
Razooky, and members of the Weinberger laboratory for helpful discussions. LSW acknowledges …
[HTML][HTML] Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity
HIV-1 Tat transactivation is vital for completion of the viral life cycle and has been implicated
in determining proviral latency. We present an extensive experimental/computational study …
in determining proviral latency. We present an extensive experimental/computational study …
Transcriptional burst frequency and burst size are equally modulated across the human genome
…, ML Simpson, LS Weinberger - Proceedings of the …, 2012 - National Acad Sciences
… We thank Hana El-Samad, Ido Golding, Jim Kadonaga, Laurie Boyer, Alex Hoffmann, John
Cooke, David Karig, and members of the Weinberger and Simpson labs for helpful comments…
Cooke, David Karig, and members of the Weinberger and Simpson labs for helpful comments…
[PDF][PDF] Transcriptional bursting from the HIV-1 promoter is a significant source of stochastic noise in HIV-1 gene expression
Abstract Analysis of noise in gene expression has proven a powerful approach for analyzing
gene regulatory architecture. To probe the regulatory mechanisms controlling expression of …
gene regulatory architecture. To probe the regulatory mechanisms controlling expression of …
[PDF][PDF] A hardwired HIV latency program
Biological circuits can be controlled by two general schemes: environmental sensing or
autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent infection …
autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent infection …
Transient-mediated fate determination in a transcriptional circuit of HIV
Steady-state behavior and bistability have been proposed as mechanisms for decision making
in gene circuits 1 , 2 , 3 . However, transient gene expression has also been proposed to …
in gene circuits 1 , 2 , 3 . However, transient gene expression has also been proposed to …
Screening for noise in gene expression identifies drug synergies
… Pai and the Weinberger lab for thoughtful discussions. We … CD, Simpson ML, Weinberger
LS, Transcriptional burst frequency … Pai and the Weinberger lab for thoughtful discussions. We …
LS, Transcriptional burst frequency … Pai and the Weinberger lab for thoughtful discussions. We …
A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions
…, RA Coleman, MMK Hansen, LS Weinberger - Science, 2021 - science.org
… Balazsi, and members of the Weinberger laboratory for thoughtful discussions and … Balazsi,
and members of the Weinberger laboratory for thoughtful discussions and suggestions; K. …
and members of the Weinberger laboratory for thoughtful discussions and suggestions; K. …
[PDF][PDF] An evolutionary role for HIV latency in enhancing viral transmission
HIV latency is the chief obstacle to eradicating HIV but is widely believed to be an evolutionary
accident providing no lentiviral fitness advantage. However, findings of latency being "…
accident providing no lentiviral fitness advantage. However, findings of latency being "…
Dynamics of protein noise can distinguish between alternate sources of gene‐expression variability
Within individual cells, two molecular processes have been implicated as sources of noise
in gene expression: (i) Poisson fluctuations in mRNA abundance arising from random birth …
in gene expression: (i) Poisson fluctuations in mRNA abundance arising from random birth …