… Lori Wirth and members of the Ellisen laboratory for helpful discussions and review of the
manuscript. This work was supported by NIH R01 DE-015945 (to LW Ellisen) and by NIH K08 …

The p53-related genes p63 and p73 exhibit significant structural homology to p53; however,
they do not function as classical tumor suppressors and are rarely mutated in human …

Importance Estrogen receptor–positive (ER+) tumors of the breast are generally highly
responsive to endocrine treatment. Although endocrine therapy is the mainstay of adjuvant …

Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal
human somatic cells but is reactivated during tumor progression. We report the cloning of a …

Previously we described joining of DNA in the 9 T cell receptor gene to DNA of an
uncharacterized locus in at (7; 9)(q34; q34. 3) chromosomal translocation from a case of human T …

… Lei and LW Ellisen, in prep.). In contrast to Redd1 +/+ MEFs, Redd1 -/- MEFs failed to down-…
Both Redd1 and Redd2 are expressed during development (Ellisen et al. 2002). However, …

Purpose Cisplatin is a chemotherapeutic agent not used routinely for breast cancer treatment.
As a DNA cross-linking agent, cisplatin may be effective treatment for hereditary BRCA1-…

SIRT6 is a member of a highly conserved family of NAD + -dependent deacetylases with
various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop …

Hypoxia induces rapid and dramatic changes in cellular metabolism, in part through inhibition
of target of rapamycin (TOR) kinase complex 1 (TORC1) activity. Genetic studies have …

Cancers of origin in the gallbladder and bile ducts are rarely curable with current modalities
of cancer treatment. Our clinical application of broad-based mutational profiling for patients …