COVID-19 affects millions of patients worldwide, with clinical presentation ranging from
isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator support. …

Importance Evolutionary medicine may provide insights into human physiology and
pathophysiology, including tumor biology. Objective To identify mechanisms for cancer resistance in …

Cancer has deep evolutionary roots and is an important source of selective pressure in
organismal evolution. Yet, we find a great deal of variation in cancer vulnerabilities across the …

Disease susceptibility and resistance are important factors for the conservation of endangered
species, including elephants. We analyzed pathology data from 26 zoos and report that …

Introduction Isocitrate dehydrogenase (IDH) mutation status and grade define subgroups of
diffuse gliomas differing based on age, tumor location, presentation, and prognosis. While …

The emergence of drug-resistant cells, most of which have a mutated TP53 gene, prevents
curative treatment in most advanced and common metastatic cancers of adults. Yet, a few, …

… In the cohort 0, the round-cell tumour types were identified in the dog (Canis l. familiaris),
the Tasmanian devil (Sarcophillus harrisii), the pygmy goat (Capra hircus), and the ring-tailed …

… Other discrepancies in our dataset compared with the Abegglen 2015 study include
differences in data interpretation (eg at-risk groups, refining the case definition) and new trends in …

Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome associated
with germline TP53 pathogenic variants. Here, we perform whole-genome sequence (WGS) …

Background The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly
understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets …