Common genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …
[HTML][HTML] Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well
understood. Structural brain differences have been associated with BD, but results from …
understood. Structural brain differences have been associated with BD, but results from …
[HTML][HTML] Subcortical volumetric abnormalities in bipolar disorder
…, C Bourne, A Bilderbeck, L Abramovic… - Molecular …, 2016 - nature.com
Considerable uncertainty exists about the defining brain changes associated with bipolar
disorder (BD). Understanding and quantifying the sources of uncertainty can help generate …
disorder (BD). Understanding and quantifying the sources of uncertainty can help generate …
[HTML][HTML] Novel genetic loci associated with hippocampal volume
…, S Desrivières, MW Vernooij, L Abramovic… - Nature …, 2017 - nature.com
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …
Novel genetic loci underlying human intracranial volume identified through genome-wide association
…, K Wittfeld, SJ Van der Lee, L Abramovic… - Nature …, 2016 - nature.com
Intracranial volume reflects the maximally attained brain size during development, and remains
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …
Genetic architecture of subcortical brain structures in 38,851 individuals
…, M Andersson, T Espeseth, O Grimm, L Abramovic… - Nature …, 2019 - nature.com
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens, …
We identified common genetic variation related to the volumes of the nucleus accumbens, …
Can structural MRI aid in clinical classification? A machine learning study in two independent samples of patients with schizophrenia, bipolar disorder and healthy …
…, M Nieuwenhuis, NEM van Haren, L Abramovic… - Neuroimage, 2014 - Elsevier
… BP percentages have been split into percentages for lithium users (L) and non-users (Ł).
Leave-4-out cross-validation was used for the M models, and leave-2-out for the MŁ models. …
Leave-4-out cross-validation was used for the M models, and leave-2-out for the MŁ models. …
[HTML][HTML] Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
The two hemispheres of the human brain differ functionally and structurally. Despite over a
century of research, the extent to which brain asymmetry is influenced by sex, handedness, …
century of research, the extent to which brain asymmetry is influenced by sex, handedness, …
Brain network analysis reveals affected connectome structure in bipolar I disorder
G Collin, MP van den Heuvel, L Abramovic… - Human brain …, 2016 - Wiley Online Library
The notion that healthy brain function emerges from coordinated neural activity constrained
by the brain's network of anatomical connections—ie, the connectome—suggests that …
by the brain's network of anatomical connections—ie, the connectome—suggests that …
High educational performance is a distinctive feature of bipolar disorder: a study on cognition in bipolar disorder, schizophrenia patients, relatives and controls
BackgroundSchizophrenia is associated with lower intelligence and poor educational
performance relative to the general population. This is, to a lesser degree, also found in first-…
performance relative to the general population. This is, to a lesser degree, also found in first-…