Common genetic variants influence human subcortical brain structures

…, N Jahanshad, R Toro, K Wittfeld, L Abramovic… - Nature, 2015 - nature.com
The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …

[HTML][HTML] Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group

…, J Houenou, LM Beard, L Rauer, L Abramovic… - Molecular …, 2018 - nature.com
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well
understood. Structural brain differences have been associated with BD, but results from …

[HTML][HTML] Subcortical volumetric abnormalities in bipolar disorder

…, C Bourne, A Bilderbeck, L Abramovic… - Molecular …, 2016 - nature.com
Considerable uncertainty exists about the defining brain changes associated with bipolar
disorder (BD). Understanding and quantifying the sources of uncertainty can help generate …

[HTML][HTML] Novel genetic loci associated with hippocampal volume

…, S Desrivières, MW Vernooij, L Abramovic… - Nature …, 2017 - nature.com
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …

Novel genetic loci underlying human intracranial volume identified through genome-wide association

…, K Wittfeld, SJ Van der Lee, L Abramovic… - Nature …, 2016 - nature.com
Intracranial volume reflects the maximally attained brain size during development, and remains
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …

Genetic architecture of subcortical brain structures in 38,851 individuals

…, M Andersson, T Espeseth, O Grimm, L Abramovic… - Nature …, 2019 - nature.com
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens, …

Can structural MRI aid in clinical classification? A machine learning study in two independent samples of patients with schizophrenia, bipolar disorder and healthy …

…, M Nieuwenhuis, NEM van Haren, L Abramovic… - Neuroimage, 2014 - Elsevier
… BP percentages have been split into percentages for lithium users (L) and non-users (Ł).
Leave-4-out cross-validation was used for the M models, and leave-2-out for the MŁ models. …

[HTML][HTML] Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

…, CD Whelan, MP Zwiers, Y Abe, L Abramovic… - Brain imaging and …, 2017 - Springer
The two hemispheres of the human brain differ functionally and structurally. Despite over a
century of research, the extent to which brain asymmetry is influenced by sex, handedness, …

Brain network analysis reveals affected connectome structure in bipolar I disorder

G Collin, MP van den Heuvel, L Abramovic… - Human brain …, 2016 - Wiley Online Library
The notion that healthy brain function emerges from coordinated neural activity constrained
by the brain's network of anatomical connections—ie, the connectome—suggests that …

High educational performance is a distinctive feature of bipolar disorder: a study on cognition in bipolar disorder, schizophrenia patients, relatives and controls

A Vreeker, MPM Boks, L Abramovic… - Psychological …, 2016 - cambridge.org
BackgroundSchizophrenia is associated with lower intelligence and poor educational
performance relative to the general population. This is, to a lesser degree, also found in first-…