Mechanotransduction refers to the conversion of mechanical forces into biochemical or
electrical signals that initiate structural and functional remodeling in cells and tissues. The heart …

Transcytosis is a widespread pathway for apical targeting in epithelial cells. MAL2, an essential
protein of the machinery for apical transcytosis, functions by shuttling in vesicular carriers …

T cell antigen receptor–proximal signaling components, Rho-family GTPases, and formin
proteins DIA1 and FMNL1 have been implicated in centrosome reorientation to the …

The MAL protein is an essential component of the specialized machinery for apical targeting
in epithelial cells. The src family kinase Lck plays a pivotal role in T cell signaling. We show …

Multiple formins regulate microtubule (MT) arrays, but whether they function individually or
in a common pathway is unknown. Lysophosphatidic acid (LPA) stimulates the formation of …

Expression of the src-family kinase lymphocyte-specific protein tyrosine kinase (Lck) at the
plasma membrane is essential for it to fulfill its pivotal role in signal transduction in T …

T cell membrane receptors and signaling molecules assemble at the immunological
synapse (IS) in a supramolecular activation cluster (SMAC), organized into two differentiated …

… (Bollig et al., 2009; Perner et al., 2007), we have previously shown that wt1a and wt1b are
initially expressed in a few proepicardial cells and later in epicardial cells (Andrés-Delgado et …

The incidence of metabolic syndrome (MetS) is increasing worldwide which makes necessary
the finding of new strategies to treat and/or prevent it. The aim of this study was to analyze …

The epicardium, the outer mesothelial layer enclosing the myocardium, plays key roles in
heart development and regeneration. During embryogenesis, the epicardium arises from the …