The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

Despite an abundance of new studies about topologically associating domains (TADs), the
role of genetic information in TAD formation is still not fully understood. Here we use our …

Metabolic reprogramming is a hallmark of activated T cells. The switch from oxidative
phosphorylation to aerobic glycolysis provides energy and intermediary metabolites for the …

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined.
We generated deep epigenomes comprising genome-wide profiles of DNA methylation, …

To date, it remains largely unclear to what extent chromatin machinery contributes to the
susceptibility and progression of complex diseases. Here, we combine deep epigenome …

Chromatin immunoprecipitation followed by next generation sequencing (ChIP-seq) is a key
technique in chromatin research. Although heavily applied, existing ChIP-seq protocols are …

Background Monocyte-to-macrophage differentiation involves major biochemical and structural
changes. In order to elucidate the role of gene regulatory changes during this process, …

Aims The Heart Failure Association of the European Society of Cardiology (HFA‐ESC)
proposed a definition of advanced heart failure (HF) that has not been validated, yet. We …

Background Partially methylated domains are extended regions in the genome exhibiting a
reduced average DNA methylation level. They cover gene-poor and transcriptionally inactive …

Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the
oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate …