Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
…, HP Soyer, V Bataille, B Dalmasso, LM Bowdler… - Nature …, 2020 - nature.com
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
[HTML][HTML] Contribution of genetic variation to transgenerational inheritance of DNA methylation
Background Despite the important role DNA methylation plays in transcriptional regulation,
the transgenerational inheritance of DNA methylation is not well understood. The genetic …
the transgenerational inheritance of DNA methylation is not well understood. The genetic …
[HTML][HTML] Identification of 55,000 replicated DNA methylation QTL
…, AK Henders, L Bowdler, JN Painter, L Murphy… - Scientific reports, 2018 - nature.com
DNA methylation plays an important role in the regulation of transcription. Genetic control of
DNA methylation is a potential candidate for explaining the many identified SNP …
DNA methylation is a potential candidate for explaining the many identified SNP …
[HTML][HTML] Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin
…, T Carrillo-Roa, AK Henders, L Bowdler… - Translational …, 2013 - nature.com
Our understanding of major depressive disorder (MDD) has focused on the influence of genetic
variation and environmental risk factors. Growing evidence suggests the additional role …
variation and environmental risk factors. Growing evidence suggests the additional role …
[HTML][HTML] Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma
risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, …
risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, …
Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339
…, S Kaufmann, HT Luong, L Bowdler… - Human molecular …, 2016 - academic.oup.com
Genome-wide association studies (GWAS) have identified markers within the WNT4 region
on chromosome 1p36.12 showing consistent and strong association with increasing …
on chromosome 1p36.12 showing consistent and strong association with increasing …
[HTML][HTML] Integrative genome-scale DNA methylation analysis of a large and unselected cohort reveals 5 distinct subtypes of colorectal adenocarcinomas
…, J Borowsky, C Liu, D McKeone, L Bowdler… - Cellular and molecular …, 2019 - Elsevier
Background & Aims Colorectal cancer is an epigenetically heterogeneous disease, however,
the extent and spectrum of the CpG island methylator phenotype (CIMP) is not clear. …
the extent and spectrum of the CpG island methylator phenotype (CIMP) is not clear. …
[HTML][HTML] Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method
Background Predicting risk of disease from genotypes is being increasingly proposed for a
variety of diagnostic and prognostic purposes. Genome-wide association studies (GWAS) …
variety of diagnostic and prognostic purposes. Genome-wide association studies (GWAS) …
Independent replication and meta-analysis for endometriosis risk loci
Y Sapkota, A Fassbender, L Bowdler… - Twin Research and …, 2015 - cambridge.org
Endometriosis is a complex disease that affects 6–10% of women in their reproductive
years and 20–50% of women with infertility. Genome-wide and candidate-gene association …
years and 20–50% of women with infertility. Genome-wide and candidate-gene association …