Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper
organogenesis, yet how the cell cycle is blocked in differentiated tissues remains unclear. …

The dorsal–ventral polarity of the somite is controlled by antagonistic signals from the dorsal
neural tube/surface ectoderm, mediated by WNTs, and from the ventral notochord, mediated …

Sonic hedgehog (Shh) signaling is essential for sclerotome development in the mouse. Gli2
and Gli3 are thought to be the primary transcriptional mediators of Shh signaling; however, …

Since the earliest observations of cells undergoing mitosis, it has been clear that there is an
intimate relationship between the cell cycle and nuclear chromatin architecture. The nuclear …

Terminal differentiation is often coupled with permanent exit from the cell cycle, yet it is unclear
how cell proliferation is blocked in differentiated tissues. We examined the process of cell …

Specification of tissue identity during development requires precise coordination of gene
expression in both space and time. Spatially, master regulatory transcription factors are …

Dorsoventral polarity of the somitic mesoderm is established by competitive signals originating
from adjacent tissues. The ventrally located notochord provides the ventralizing signals to …

… We would like to thank members of the Buttitta and Cheng-Yu Lee labs for helpful discussions
and suggestions. We also thank Yiqin Ma, Kerry Flegel, Chelsea Yu, Emily Lerner, Ashley …

During terminal differentiation, most cells exit the cell cycle and enter into a prolonged or
permanent G0 in which they are refractory to mitogenic signals. Entry into G0 is usually initiated …

Terminally differentiated cells of the nervous system have long been considered to be in a
stable non-cycling state and are often considered to be permanently in G0. Exit from the cell …