La protéine découplante 2 (UCP-2) fait partie de la famille des transporteurs anioniques
mitochondriaux. Elle est exprimée dans toutes les cellules, mais elle se trouve principalement …

Normal mitochondria function in maintaining the cellular energy equilibrium by providing
energy in the form of ATP according to energy demand of the cell. This is obtained by a close …

Adipocytes participate in the microenvironment of the bone marrow (BM), but their exact role
remains to be determined. It has recently been shown that leptin, a hormone secreted from …

Most of the oxygen consumed by aerobic organisms is reduced to water by the enzyme
cytochrome c oxidase in the terminal reaction of the mitochondrial respiratory chain. A significant …

Obese patients have chronic, low-grade inflammation that predisposes to type 2 diabetes
and results, in part, from dysregulated visceral white adipose tissue (WAT) functions. The …

INTRODUCTION Adipose cells are found in multiple locations in man and are traditionally
divided into two major types. White adipose cells are mainly involved in lipid metabolism and …

According to the state of mitochondrial respiration, the respiratory chain generates
superoxide anions converted into hydrogen peroxide. Two uncoupling proteins (UCP) able to …

Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a
low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin …

Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in
cultures of developed organs, are of unknown identity and native distribution. We have …

Background aims Adipose tissue is a rich and very convenient source of cells for regenerative
medicine therapeutic approaches. However, a characterization of the population of …