User profiles for L. Cherkezyan

Lusik Cherkezyan

Research Associate in Biomedical Engineering, Northwestern University
Verified email at u.northwestern.edu
Cited by 805

[HTML][HTML] Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study

L Cherkezyan, Y Stypula-Cyrus, H Subramanian… - BMC cancer, 2014 - Springer
… functions was created with values of D ranging from 2 to 6 and l c ranging from 0.66r max
to r max . The values of D and l c , which yield the best agreement (evaluated via r-squared …

[HTML][HTML] The global relationship between chromatin physical topology, fractal structure, and gene expression

…, A Tiwari, PT Ruhoff, Y Stypula-Cyrus, L Cherkezyan… - Scientific reports, 2017 - nature.com
… in L d (R 2 > 0.8) and utilized as an internal control genes that were significantly altered but
uncorrelated with L d (R 2 < 0.01). At baseline, we found that genes highly correlated with L d …

[HTML][HTML] Linker histones are fine-scale chromatin architects modulating developmental decisions in Arabidopsis

…, TN Fabrice, S Fritz, S Grob, C Ringli, L Cherkezyan… - Genome Biology, 2019 - Springer
Background Chromatin provides a tunable platform for gene expression control. Besides the
well-studied core nucleosome, H1 linker histones are abundant chromatin components with …

Interferometric spectroscopy of scattered light can quantify the statistics of subdiffractional refractive-index fluctuations

L Cherkezyan, I Capoglu, H Subramanian, JD Rogers… - Physical review …, 2013 - APS
Despite major importance in physics, biology, and other sciences, the optical sensing of
nanoscale structures in the far zone remains an open problem due to the fundamental diffraction …

Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopy

…, S Gladstein, L Cherkezyan… - Proceedings of the …, 2016 - National Acad Sciences
… We also note that the rate of Σ increase with L c decays as the L c increases, with Σ peaking
at L c near 75 nm. These simulations represent one component, L c , of the signal captured …

Protocol optimization considerations for implementing deep learning CT reconstruction

…, B Nett, L Cherkezyan… - American Journal of …, 2021 - Am Roentgen Ray Soc
OBJECTIVE. Previous advances over filtered back projection (FBP) have incorporated
model-based iterative reconstruction. The purpose of this study was to characterize the latest …

Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization

…, DK Rex, MJ Goldberg, J Muldoon, L Cherkezyan… - Cancer research, 2012 - AACR
… We also studied the effect of several demographic factors on L d . Furthermore, using rectal
L d as a single marker, we developed the prediction rule in a training set containing controls …

Macrogenomic engineering via modulation of the scaling of chromatin packing density

…, GM Bauer, W Wu, L Cherkezyan… - Nature biomedical …, 2017 - nature.com
Many human diseases result from the dysregulation of the complex interactions between
tens to thousands of genes. However, approaches for the transcriptional modulation of many …

Review of interferometric spectroscopy of scattered light for the quantification of subdiffractional structure of biomaterials

L Cherkezyan, D Zhang… - … of biomedical optics, 2017 - spiedigitallibrary.org
… in terms of the effective correlation length l c eff in case of (c) L = 0.5 μ m and (d) L = 2 μ m .
… reach L and therefore saturates below it at L / l c ≤ 3 ). Expectedly, the effect of a finite L on r …

Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening

VJA Konda, L Cherkezyan, H Subramanian… - …, 2013 - thieme-connect.com
… The aim of this study was to assess the disorder strength (L d ), as measured by PWS, in
normal squamous epithelium in the proximal esophagus to determine whether nanoscale …