User profiles for L. Coughlan
 | Lynda CoughlanUniversity of Maryland School of Medicine Verified email at som.umaryland.edu Cited by 3298 |
[HTML][HTML] New weapons to fight old enemies: novel strategies for the (bio) control of bacterial biofilms in the food industry
Biofilms are microbial communities characterized by their adhesion to solid surfaces and the
production of a matrix of exopolymeric substances, consisting of polysaccharides, proteins, …
production of a matrix of exopolymeric substances, consisting of polysaccharides, proteins, …
[HTML][HTML] Factors which contribute to the immunogenicity of non-replicating adenoviral vectored vaccines
L Coughlan - Frontiers in immunology, 2020 - frontiersin.org
… Figure is updated from Coughlan et al. (18) and was created with ©BioRender - biorender.…
Figure is updated from Coughlan et al. (108) and Holst and Thomsen (138) and was created …
Figure is updated from Coughlan et al. (108) and Holst and Thomsen (138) and was created …
Biofilms in food processing environments: challenges and opportunities
A Alvarez-Ordóñez, LM Coughlan… - Annual Review of …, 2019 - annualreviews.org
This review examines the impact of microbial communities colonizing food processing
environments in the form of biofilms on food safety and food quality. The focus is both on biofilms …
environments in the form of biofilms on food safety and food quality. The focus is both on biofilms …
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins interact with
the eukaryotic translation machinery, and inhibitors of translation have potent antiviral effects. …
the eukaryotic translation machinery, and inhibitors of translation have potent antiviral effects. …
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome
…, LA Machiesky, M Heurich, BM Nagalo, L Coughlan… - Science …, 2021 - science.org
Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26
(HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe …
(HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe …
[HTML][HTML] A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled …
…, JM Carreño, V Chromikova, C Claeys, L Coughlan… - Nature medicine, 2021 - nature.com
Seasonal influenza viruses constantly change through antigenic drift and the emergence of
pandemic influenza viruses through antigenic shift is unpredictable. Conventional influenza …
pandemic influenza viruses through antigenic shift is unpredictable. Conventional influenza …
[HTML][HTML] A multi-targeting, nucleoside-modified mRNA influenza virus vaccine provides broad protection in mice
…, D Weissman, F Krammer, L Coughlan… - Molecular Therapy, 2020 - cell.com
Influenza viruses are respiratory pathogens of public health concern worldwide with up to
650,000 deaths occurring each year. Seasonal influenza virus vaccines are employed to …
650,000 deaths occurring each year. Seasonal influenza virus vaccines are employed to …
[HTML][HTML] Broadly neutralizing antibodies target a haemagglutinin anchor epitope
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus
have the potential to provide near universal protection against influenza virus infection 1 . …
have the potential to provide near universal protection against influenza virus infection 1 . …
[HTML][HTML] Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens
RD Antrobus, L Coughlan, TK Berthoud, MD Dicks… - Molecular therapy, 2014 - cell.com
Adenoviruses are potent vectors for inducing and boosting cellular immunity to encoded
recombinant antigens. However, the widespread seroprevalence of neutralizing antibodies to …
recombinant antigens. However, the widespread seroprevalence of neutralizing antibodies to …
Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide
pandemic with high morbidity and mortality. Development of animal models that recapitulate …
pandemic with high morbidity and mortality. Development of animal models that recapitulate …