User profiles for L. Daigle Tanya
Tanya L. DaigleAllen Institute for Brain Science Verified email at alleninstitute.org Cited by 6626 |
GRK2: multiple roles beyond G protein-coupled receptor desensitization
G protein-coupled receptor kinases (GRKs) regulate numerous G protein-coupled receptors
(GPCRs) by phosphorylating the intracellular domain of the active receptor, resulting in …
(GPCRs) by phosphorylating the intracellular domain of the active receptor, resulting in …
[HTML][HTML] Shared and distinct transcriptomic cell types across neocortical areas
The neocortex contains a multitude of cell types that are segregated into layers and functionally
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …
[HTML][HTML] Comparative cellular analysis of motor cortex in human, marmoset and mouse
…, T Casper, RG Castanon, K Crichton, TL Daigle… - Nature, 2021 - nature.com
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …
[HTML][HTML] Morphological diversity of single neurons in molecularly defined cell types
Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types 1 , 2 , yet our knowledge of its diversity remains limited. Here, to …
feature of neuronal types 1 , 2 , yet our knowledge of its diversity remains limited. Here, to …
[PDF][PDF] A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality
Modern genetic approaches are powerful in providing access to diverse cell types in the brain
and facilitating the study of their function. Here, we report a large set of driver and reporter …
and facilitating the study of their function. Here, we report a large set of driver and reporter …
[PDF][PDF] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells
…, T Braun, K Brouner, T Casper, K Crichton, TL Daigle… - Cell, 2020 - cell.com
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …
or genetic attributes. To better constrain the definition of neuronal cell types, we …
Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics
The development of the living acute brain slice preparation for analyzing synaptic function
roughly a half century ago was a pivotal achievement that greatly influenced the landscape of …
roughly a half century ago was a pivotal achievement that greatly influenced the landscape of …
Local connectivity and synaptic dynamics in mouse and human neocortex
We present a unique, extensive, and open synaptic physiology analysis platform and dataset.
Through its application, we reveal principles that relate cell type to synaptic properties and …
Through its application, we reveal principles that relate cell type to synaptic properties and …
Classification of electrophysiological and morphological neuron types in the mouse visual cortex
…, P Chong, K Crichton, C Cuhaciyan, TL Daigle… - Nature …, 2019 - nature.com
Understanding the diversity of cell types in the brain has been an enduring challenge and
requires detailed characterization of individual neurons in multiple dimensions. To …
requires detailed characterization of individual neurons in multiple dimensions. To …
Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling
Molecular mechanisms regulating the development of physiological and behavioral
tolerance to cannabinoids are not well understood. Two cellular correlates implicated in the …
tolerance to cannabinoids are not well understood. Two cellular correlates implicated in the …