G protein-coupled receptor kinases (GRKs) regulate numerous G protein-coupled receptors
(GPCRs) by phosphorylating the intracellular domain of the active receptor, resulting in …

The neocortex contains a multitude of cell types that are segregated into layers and functionally
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types 1 , 2 , yet our knowledge of its diversity remains limited. Here, to …

Modern genetic approaches are powerful in providing access to diverse cell types in the brain
and facilitating the study of their function. Here, we report a large set of driver and reporter …

Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

The development of the living acute brain slice preparation for analyzing synaptic function
roughly a half century ago was a pivotal achievement that greatly influenced the landscape of …

We present a unique, extensive, and open synaptic physiology analysis platform and dataset.
Through its application, we reveal principles that relate cell type to synaptic properties and …

Understanding the diversity of cell types in the brain has been an enduring challenge and
requires detailed characterization of individual neurons in multiple dimensions. To …

Molecular mechanisms regulating the development of physiological and behavioral
tolerance to cannabinoids are not well understood. Two cellular correlates implicated in the …