… Spinal cord neurons were isolated as outlined above and plated on glass coverslips coated
in poly-l-lysine (24 hours, Sigma-Aldrich) followed by laminin (5 mg/mL 2 hours, Sigma-…

Nociception is a fundamental acute protective mechanism that prevents harm to an organism.
Understanding the integral processes that control nociceptive processing are fundamental …

Chemotherapy causes sensory disturbances in cancer patients that results in neuropathies
and pain. As cancer survivorships has dramatically increased over the past 10 years, pain …

Chemotherapy-induced peripheral sensory neuropathy (CIPN) is a highly prevalent adverse
health related comorbidity that manifests later in life in adult patients who have undergone …

Vascular disturbance is a key factor in the development of neurological disease, with reduced
integrity of the capillary network in the dorsal horn implicated in activation of nociceptive …

Metabolic dysfunction in skeletal muscle disturbs its contractile response as well as its
innervation and vascular networks. The molecular drivers responsible for affecting decline in …

The spinal cord, a compartment of the central nervous system, is made up of a number of
architecturally distinct neural centers that influence an array of neurophysiological systems. …

Neuropathic pain such as that seen in diabetes mellitus, results in part from central
sensitisation in the spinal cord dorsal horn. However, the mechanisms responsible for such …

… ACE2 showed reduced expression in high glucose (47 mmol/l, 29.27%↓ *P<0.035, n=5)
compared to normal glucose (17 mmol/l, n=3) environments. These data demonstrate that …

Obesity, a complex metabolic disorder characterised by excessive adipose tissue accumulation,
is associated with numerous health complications. This study aimed to investigate the …