It has been more than 50 years since the elucidation of the structure of double-helical DNA.
Despite active research and progress in DNA biology and biochemistry, much remains to be …

The tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase (SDH) is a tumor
suppressor. Heterozygosity for defective SDH subunit genes predisposes to familial …

We have recently identified an RNA aptamer for the transcription factor NF-κB p50 homodimer
[(p50) 2 ], which exhibits little sequence resemblance to the consensus DNA target for (p50…

Multifunctional proteins challenge the conventional ‘one protein–one function’ paradigm.
Here we note apparent multifunctional proteins with nucleic acid partners, tabulating eight …

DNA is often bent when complexed with proteins. Understanding the forces responsible for
DNA bending would be of fundamental value in exploring the interplay of these …

Certain sequences of double‐helical DNA can be recognized and tightly bound by
oligonucleotides. The effects of such triple‐helical structures on DNA binding proteins have been …

… L. James Maher III 1 … Motivated by this idea, Strauss & Maher simulated the electrostatic
consequences of protein binding by chemical synthesis of DNA duplexes in which the phosphate …

… Cassiday, L. James Maher. Yeast genetic selections to optimize RNA decoys for transcription
factor NF-κB. Proceedings of the National Academy of Sciences 2003, 100 (7) , 3930-3935. …

Fluoroquinolones (FQ) are powerful broad-spectrum antibiotics whose side effects include
renal damage and, strangely, tendinopathies. The pathological mechanisms underlying these …

Succinylation is a post-translational protein acylation modification that converts the cationic
lysine side chain to an anion with large potential impacts on protein structure and function. …