Until recently, recombination studies in humans and mice had identified only a few anecdotal
examples of crossover hot spots. Recently, the pace of discovery has accelerated. In every …

There is considerable interest in understanding patterns of linkage disequilibrium (LD) in the
human genome, to aid investigations of human evolution and facilitate association studies …

The tricky path to recombining X and Y chromosomes in meiosis - Kauppi - 2012 - Annals of
the New York Academy of Sciences - Wiley Online Library … Liisa Kauppi … Liisa Kauppi …

The production of gametes (sperm and eggs in mammals) involves two sequential cell divisions,
meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to different …

Humans suffer from high rates of fetal aneuploidy, often arising from the absence of meiotic
crossover recombination between homologous chromosomes 1 . Meiotic recombination is …

Meiosis requires that each chromosome find its homologous partner and undergo at least
one crossover. XY chromosome segregation hinges on efficient crossing-over in a very small …

Different organisms display widely different numbers of the programmed double-strand
breaks (DSBs) that initiate meiotic recombination (eg, hundreds per meiocyte in mice and …

… Howarth, Lea Kauppi and Jeff Herrick, as well as many other … Source: IRP WG L+S
based on various references …

Purpose: Homologous recombination deficiency (HRD) correlates with platinum sensitivity
in patients with ovarian cancer, which clinically is the most useful predictor of sensitivity to …

Sex chromosomes in males of most eutherian mammals share only a small homologous
segment, the pseudoautosomal region (PAR), in which the formation of double-strand breaks (…