Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …

The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological, …

Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …

Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

Background Cognitive impairment is a clinically important feature of schizophrenia. Polygenic
risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, …

The role of the human microbiome in health and disease is increasingly appreciated. We
studied the composition of microbial communities present in blood across 192 individuals, …

Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown.
Among the most well-replicated findings in neurobiological studies of schizophrenia are …

Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing
neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to eg, autism …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …