Objective To perform a systematic review of the global prevalence of low back pain, and to
examine the influence that case definition, prevalence period, and other variables have on …

Background Quantification of the disease burden caused by different risks informs
prevention by providing an account of health loss different to that provided by a disease-by-disease …

Background Reliable and timely information on the leading causes of death in populations,
and how these are changing, is a crucial input into health policy debates. In the Global …

Objective To estimate the global burden of hip and knee osteoarthritis (OA) as part of the
Global Burden of Disease 2010 study and to explore how the burden of hip and knee OA …

… L Sànchez-Riera E Carnahan T Vos L Veerman R Norman SS Lim D Hoy E Smith N
Wilson JM Nolla JS Chen M Macara N Kamalaraj Y Li C Kok C Santos-Hernández L March …

Biological aging is attributed to progressive dysfunction in systems governing genetic and
metabolic integrity. At the cellular level, aging is evident by accumulated DNA damage and …

Background— The delivery of autologous cells to increase angiogenesis is emerging as a
treatment option for patients with cardiovascular disease but may be limited by the …

Vascular smooth muscle cell (VSMC) proliferation promotes intimal hyperplasia (IH) in
occluding vascular diseases. Here we identified a positive role of ALDH1A3 (an aldehyde …

Aims Metabolic function/dysfunction is central to aging biology. This is well illustrated by the
Polymerase Gamma (POLG) mutant mouse where a key residue of the mitochondrial DNA …

Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication.
Here we show a noncanonical PLK4 function of regulating the transcription factor SRF’…