… Chen, EK Wakeland, and L. Morel, “The major murine systemic lupus erythematosus
susceptibility locus Sle1 results in abnormal functions of both B and T cells,” Journal of Immunology…

… ‘2 l?acbsimulatedautosomea7mp&eda&3tof~lociatap&i& points and associated flags denoting
the boundaries … which the homologous donor segment (lacking the transgene or l’elerxon, …

… -derived Nba2 locus was shown to induce disease when crossed to NZW without affecting
the size of the B-1 cell compartment [49] and the same observation was made for Sle1 (Morel …

The standard model of particle physics is remarkably successful because it is consistent with
(almost) all experimental results. However, it fails to explain dark matter, dark energy and …

… Briefly, BMESL cells were suspended in IMDM containing 2 mM l-glutamine, 100 U ml −1
penicillin, 100 µg ml −1 streptomycin, 20% FCS and 300 µM monothioglycerol (Sigma). Cells …

… L) and CD71 (M) in total, T n , and T em T cells. n = 4 to 14. MFI, mean fluorescence intensity.
… S11, H to L). Although 2DG lowered immune complex deposition in the kidneys (fig. S11, M …

… immunosorbent assay, using circular plasmid DNA (400 uglml) coated on 96-well polystyrene
microtiter plates precoated with 80 pglml of poly-L-lysine (Sigma Chemical Co.). Sera …

We previously produced three congenic strains carrying lupus susceptibility genes (Sle1-Sle3)
from the lupus-prone NZM2410 mouse on the C57BL/6 background and characterized …

Perisynaptic astrocytes express important glutamate transporters, especially excitatory amino
acid transporter 2 (EAAT2, rodent analog GLT1) to regulate extracellular glutamate levels …

The major murine systemic lupus erythematosus (SLE) susceptibility locus Sle1 is syntenic
to a chromosomal region linked with SLE susceptibility in multiple human studies. Congenic …