The ability to respond to various intracellular and/or extracellular stresses allows the
organism to adapt to changing environmental conditions and drives evolution. It is now well …

… In parallel, studies in this mouse model also demonstrate that NCoR1 participates in liver
X receptor (LXR) signaling, as the expression of LXR targets was induced in the liver of L-…

Nicotinamide adenine dinucleotide (NAD) is a central metabolic cofactor by virtue of its
redox capacity, and as such regulates a wealth of metabolic transformations. However, the …

NAD + is an important cofactor regulating metabolic homeostasis and a rate-limiting
substrate for sirtuin deacylases. We show that NAD + levels are reduced in aged mice and …

Longevity is regulated by a network of closely linked metabolic systems. We used a
combination of mouse population genetics and RNA interference in Caenorhabditis elegans to …

The biological effects of urolithins remain poorly characterized, despite wide-spread human
exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which …

Alzheimer’s disease is a common and devastating disease characterized by aggregation of
the amyloid-β peptide. However, we know relatively little about the underlying molecular …

In recent years, tetracyclines, such as doxycycline, have become broadly used to control
gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct …

Neuromuscular diseases are often caused by inherited mutations that lead to progressive
skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, …

We previously demonstrated that the deletion of the poly(ADP-ribose)polymerase (Parp)-1
gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity…