User profiles for L. O’Driscoll

Lorraine O'Driscoll

Trinity College Dublin, School of Pharmacy & Pharmaceutical Sciences & Biomedical …
Verified email at tcd.ie
Cited by 29274

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies

S O'Neill, L O'Driscoll - Obesity reviews, 2015 - Wiley Online Library
Obesity is reaching epidemic proportions with recent worldwide figures estimated at 1.4 billion
and rising year‐on‐year. Obesity affects all socioeconomic backgrounds and ethnicities …

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

…, LM Mus, DC Muth, A Németh, L O'Driscoll… - Nature …, 2017 - nature.com
We argue that the field of extracellular vesicle (EV) biology needs more transparent reporting
to facilitate interpretation and replication of experiments. To achieve this, we describe EV-…

Biological properties of extracellular vesicles and their physiological functions

…, TA Nyman, L O'Driscoll… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper

…, FA Court, HA Portillo, L O'Driscoll… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Three-dimensional cell culture: the missing link in drug discovery

S Breslin, L O'Driscoll - Drug discovery today, 2013 - Elsevier
Cells, grown as monolayers (2D models), are routinely used as initial model systems for
evaluating the effectiveness and safety of libraries of molecules with potential as therapeutic …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles

KW Witwer, DCI Goberdhan, L O'Driscoll… - Journal of …, 2021 - Wiley Online Library
The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field‐consensus
rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last …

Matrix metalloproteinase expression and production by alveolar macrophages in emphysema

GA Finlay, LR O'DRISCOLL, KJ Russell… - American journal of …, 1997 - atsjournals.org
The aim of this study was to examine the hypothesis that alveolar macrophages represent a
significant source of matrix-degrading proteinases in the emphysematous lung. …

Evidence-based clinical use of nanoscale extracellular vesicles in nanomedicine

S Fais, L O'Driscoll, FE Borras, E Buzas, G Camussi… - 2016 - ACS Publications
Recent research has demonstrated that all body fluids assessed contain substantial amounts
of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid …

[HTML][HTML] Docetaxel-resistance in prostate cancer: evaluating associated phenotypic changes and potential for resistance transfer via exosomes

…, R McDermott, W Watson, J Crown, L O'Driscoll - PloS one, 2012 - journals.plos.org
Background Hormone-refractory prostate cancer remains hindered by inevitable progression
of resistance to first-line treatment with docetaxel. Recent studies suggest that phenotypic …