Purinergic mechanisms in neuroinflammation: an update from molecules to behavior

…, F Gölöncsér, G Horváth, K Bekő, L Otrokocsi… - …, 2016 - Elsevier
The principle functions of neuroinflammation are to limit tissue damage and promote tissue
repair in response to pathogens or injury. While neuroinflammation has utility, …

Microglia actively remodel adult hippocampal neurogenesis through the phagocytosis secretome

…, I Bernales, A Schulz, L Otrokocsi… - Journal of …, 2020 - Soc Neuroscience
During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are
rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. …

Effect of storage on physical and functional properties of extracellular vesicles derived from neutrophilic granulocytes

…, KA Marosvari, DS Veres, L Otrokocsi… - Journal of …, 2014 - Taylor & Francis
Aim To carry out a systematic study on the effect of different storage conditions on the number
as well as the physical and functional properties of antibacterial extracellular vesicles (EVs…

Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders

L Huang, L Otrokocsi, B Sperlágh - Brain Research Bulletin, 2019 - Elsevier
The purinergic signaling system, including P2 receptors, plays an important role in various
central nervous system (CNS) disorders. Over the last few decades, a substantial amount of …

[HTML][HTML] Novel (Hetero) arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease

…, S Kulcsár, L Otrokocsi, Á Kittel, A Pinna, L Frau… - Molecular …, 2016 - Springer
… inhibit the enzyme responsible for the intracellular degradation of dopamine, thereby
increasing dopamine availability in the nigrostriatal pathway and prolonging the effectiveness of L-…

P2X7 receptors drive poly (I: C) induced autism-like behavior in mice

G Horváth, L Otrokocsi, K Beko, M Baranyi… - Journal of …, 2019 - Soc Neuroscience
… K, L, MIA decreased the intensity of TBR1 immunoreactivity in the developing (E14.5) cortical
plate … L, Representative EM image of synaptosomes. Asterisk indicates malformed. Arrows …

[HTML][HTML] Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway

…, F Gölöncsér, V Román, B Lendvai, L Otrokocsi… - Brain, Behavior, and …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition caused by
interactions of environmental and genetic factors. Recently we showed that activation of the …

P2X7 receptors drive spine synapse plasticity in the learned helplessness model of depression

L Otrokocsi, Á Kittel, B Sperlágh - International Journal of …, 2017 - academic.oup.com
Background Major depressive disorder is characterized by structural and functional abnormalities
of cortical and limbic brain areas, including a decrease in spine synapse number in …

[HTML][HTML] The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: signalling pathway and novel therapeutic targets

A Iring, A Tóth, M Baranyi, L Otrokocsi, LV Módis… - Pharmacological …, 2022 - Elsevier
Parkinson’s disease (PD) is a chronic, progressive neurodegenerative condition; characterized
with the degeneration of the nigrostriatal dopaminergic pathway and neuroinflammation. …

Involvement of P2Y12 receptors in a nitroglycerin‐induced model of migraine in male mice

…, A Iring, L Hricisak, L Otrokocsi… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose P2Y 12 receptors regulate different forms of pain and inflammation.
In this study, we investigated the participation of P2Y 12 receptors in an animal model of …