Great efforts and expense have been expended in attempts to detect genetic polymorphisms
contributing to susceptibility to complex human disease. Concomitantly, technology for …

The apical (outward-facing) membranes of high-resistance epithelia contain Na+ channels,
traditionally identified by their sensitivity to block by the K(+)-sparing diuretic amiloride. Such …

The study of biomineralization is not only important to gain an understanding of how mineral-rich
tissues are created in vivo but also because it is a great source of inspiration for the …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

The opportunity to harness the RNA interference (RNAi) pathway to silence disease-causing
genes holds great promise for the development of therapeutics directed against targets that …

1. Using the two-dimensional (2D) spatial and spectral response profiles described in the
previous two reports, we test Daugman's generalization of Marcelja's hypothesis that simple …

Arrays of electrodes for recording and stimulating the brain are used throughout clinical
medicine and basic neuroscience research, yet are unable to sample large areas of the brain …

A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

In a series of microcosm and field studies, we have observed that over time V. cholerae and
related human pathogens enter a viable but non-culturable state. Direct viable counts by …

Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …