Background Genome-wide association studies (GWAS) in Parkinson's disease have increased
the scope of biological knowledge about the disease over the past decade. We aimed to …

Background Human genetics research lacks diversity; over 80% of genome‐wide association
studies have been conducted on individuals of European ancestry. In addition to limiting …

Genetic factors are central to the etiology of neurodegeneration, both as monogenic causes
of heritable disease and as modifiers of susceptibility to complex, sporadic disorders. Over …

Background Increasing evidence supports an extensive and complex genetic contribution to
PD. Previous genome‐wide association studies (GWAS) have shed light on the genetic …

Parkinson's disease is a highly heterogeneous disorder, where genetic factors are likely to
contribute to clinical variability, including susceptibility to cognitive impairment and dementia. …

Importance Substantial genome-wide association study (GWAS) work in Parkinson disease (PD)
has led to the discovery of an increasing number of loci shown reliably to be associated …

Parkinson’s disease is a genetically complex disorder. Multiple genes have been shown to
contribute to the risk of Parkinson’s disease, and currently 90 independent risk variants have …

A rare variant in TREM2 (p.R47H, rs75932628) was recently reported to increase the risk of
Alzheimer's disease (AD) and, subsequently, other neurodegenerative diseases, ie …

Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during
REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more …

Objective To determine if any association between previously identified alleles that confer
risk for Parkinson disease and variables measuring disease progression. Methods We …