Strategies to prolong the plasma residence time of peptide drugs
L Pollaro, C Heinis - MedChemComm, 2010 - pubs.rsc.org
… A 40 kDa polymer of this format with l = 420–510 was linked to the N-terminus of interferon
α-2a.20 (2) Structure of polysialic acid. N-acetylneuraminic acid units are linked via α-(2 → 8) …
α-2a.20 (2) Structure of polysialic acid. N-acetylneuraminic acid units are linked via α-(2 → 8) …
[PDF][PDF] Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases
V Baeriswyl, H Rapley, L Pollaro, C Stace… - …, 2012 - bicycletherapeutics.com
Peptide macrocyles can bind with high affinity and specificity to disease targets and hence
are an attractive molecule class for the development of therapeutics. Several peptide …
are an attractive molecule class for the development of therapeutics. Several peptide …
Bicyclic peptides conjugated to an albumin-binding tag diffuse efficiently into solid tumors
L Pollaro, S Raghunathan, J Morales-Sanfrutos… - Molecular cancer …, 2015 - AACR
… /L) in aqueous buffer (20 mmol/L NH 4 HCO 3 , pH 8.0), TBMB was added (2 mL, 5 mmol/L …
The final concentrations in the reaction mixture were 0.5 mmol/L crude peptide, 1 mmol/L …
The final concentrations in the reaction mixture were 0.5 mmol/L crude peptide, 1 mmol/L …
Label free 3D analysis of organelles in living cells by refractive index shows pre-mitotic organelle spinning in mammalian stem cells
PA Sandoz, C Tremblay, S Equis, S Pop, L Pollaro… - BioRxiv, 2018 - biorxiv.org
Holo-tomographic microscopy (HTM) is a label-free non-phototoxic microscopy method
reporting the fine changes of a cell’s refractive indexes (RI) in 3D. By combining HTM with …
reporting the fine changes of a cell’s refractive indexes (RI) in 3D. By combining HTM with …
Stain‐free 3D nanoscopy of living cells: a new holographic tomographic microscope for quantitative and non‐invasive 3D live cell nanoscopy
L Pollaro, S Equis, B Dalla Piazza, Y Cotte - Optik & Photonik, 2016 - Wiley Online Library
The cell is the basis of all life on earth. Therefore, being capable of directly observing and
measuring the internal parts of a living cell would open a wealth of possibilities. However, due …
measuring the internal parts of a living cell would open a wealth of possibilities. However, due …
Digital staining: microscopy of live cells without invasive chemicals
L Pollaro, B Dalla Piazza, Y Cotte - Microscopy Today, 2015 - academic.oup.com
Materials and Methods Tomography of cells. By a combination of holography [2] and rotational
scanning [3], the system detects changes to light as it propagates through the cell. The …
scanning [3], the system detects changes to light as it propagates through the cell. The …
Measuring net protease activities in biological samples using selective peptidic inhibitors
L Pollaro, P Diderich, A Angelini, S Bellotto… - Analytical …, 2012 - Elsevier
The measurement of activities from individual proteases in biological samples is difficult
because of the numerous proteases, their overlapping activities, and the lack of specific …
because of the numerous proteases, their overlapping activities, and the lack of specific …
Disloyal computer use and the computer fraud and abuse act: Narrowing the scope
G Pollaro - Duke L. & Tech. Rev., 2010 - HeinOnline
Congress drafted the Computer Fraud andAbuse Act (CFAA) to protect government interest
computersfrom malicious attacks by hackers. As computer use has expanded in the years …
computersfrom malicious attacks by hackers. As computer use has expanded in the years …
[PDF][PDF] Effects of Stimulus Periodicity on Temporal Position Learning in a Rapid Serial Visual Presentation (RSVP) Task
M Key, L Pollaro, A Musselman, G Simmons, JC Shin - researchgate.net
Conclusions • Attentional change took place over two time scales—one monotonic over the
course of the whole RSVP series and one oscillatory reflecting the expected time course of …
course of the whole RSVP series and one oscillatory reflecting the expected time course of …
Imaging alveolar–capillary gas transfer using hyperpolarized 129Xe MRI
B Driehuys, GP Cofer, J Pollaro… - Proceedings of the …, 2006 - National Acad Sciences
Effective pulmonary gas exchange relies on the free diffusion of gases across the thin tissue
barrier separating airspace from the capillary red blood cells (RBCs). Pulmonary pathologies…
barrier separating airspace from the capillary red blood cells (RBCs). Pulmonary pathologies…