Strategies to prolong the plasma residence time of peptide drugs

L Pollaro, C Heinis - MedChemComm, 2010 - pubs.rsc.org
… A 40 kDa polymer of this format with l = 420–510 was linked to the N-terminus of interferon
α-2a.20 (2) Structure of polysialic acid. N-acetylneuraminic acid units are linked via α-(2 → 8) …

[PDF][PDF] Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases

V Baeriswyl, H Rapley, L Pollaro, C Stace… - …, 2012 - bicycletherapeutics.com
Peptide macrocyles can bind with high affinity and specificity to disease targets and hence
are an attractive molecule class for the development of therapeutics. Several peptide …

Bicyclic peptides conjugated to an albumin-binding tag diffuse efficiently into solid tumors

L Pollaro, S Raghunathan, J Morales-Sanfrutos… - Molecular cancer …, 2015 - AACR
… /L) in aqueous buffer (20 mmol/L NH 4 HCO 3 , pH 8.0), TBMB was added (2 mL, 5 mmol/L
The final concentrations in the reaction mixture were 0.5 mmol/L crude peptide, 1 mmol/L

Label free 3D analysis of organelles in living cells by refractive index shows pre-mitotic organelle spinning in mammalian stem cells

PA Sandoz, C Tremblay, S Equis, S Pop, L Pollaro… - BioRxiv, 2018 - biorxiv.org
Holo-tomographic microscopy (HTM) is a label-free non-phototoxic microscopy method
reporting the fine changes of a cell’s refractive indexes (RI) in 3D. By combining HTM with …

Stain‐free 3D nanoscopy of living cells: a new holographic tomographic microscope for quantitative and non‐invasive 3D live cell nanoscopy

L Pollaro, S Equis, B Dalla Piazza, Y Cotte - Optik & Photonik, 2016 - Wiley Online Library
The cell is the basis of all life on earth. Therefore, being capable of directly observing and
measuring the internal parts of a living cell would open a wealth of possibilities. However, due …

Digital staining: microscopy of live cells without invasive chemicals

L Pollaro, B Dalla Piazza, Y Cotte - Microscopy Today, 2015 - academic.oup.com
Materials and Methods Tomography of cells. By a combination of holography [2] and rotational
scanning [3], the system detects changes to light as it propagates through the cell. The …

Measuring net protease activities in biological samples using selective peptidic inhibitors

L Pollaro, P Diderich, A Angelini, S Bellotto… - Analytical …, 2012 - Elsevier
The measurement of activities from individual proteases in biological samples is difficult
because of the numerous proteases, their overlapping activities, and the lack of specific …

Disloyal computer use and the computer fraud and abuse act: Narrowing the scope

G Pollaro - Duke L. & Tech. Rev., 2010 - HeinOnline
Congress drafted the Computer Fraud andAbuse Act (CFAA) to protect government interest
computersfrom malicious attacks by hackers. As computer use has expanded in the years …

[PDF][PDF] Effects of Stimulus Periodicity on Temporal Position Learning in a Rapid Serial Visual Presentation (RSVP) Task

M Key, L Pollaro, A Musselman, G Simmons, JC Shin - researchgate.net
Conclusions • Attentional change took place over two time scales—one monotonic over the
course of the whole RSVP series and one oscillatory reflecting the expected time course of …

Imaging alveolar–capillary gas transfer using hyperpolarized 129Xe MRI

B Driehuys, GP Cofer, J Pollaro… - Proceedings of the …, 2006 - National Acad Sciences
Effective pulmonary gas exchange relies on the free diffusion of gases across the thin tissue
barrier separating airspace from the capillary red blood cells (RBCs). Pulmonary pathologies…