The high global prevalence of depression, together with the recent acceleration of remote
care owing to the COVID-19 pandemic, has prompted increased interest in the efficacy of …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

Background Personality is suggested to be a major risk factor for depression but large‐scale
individual participant meta‐analyses on this topic are lacking. Method Data from 10 …

Importance Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for …

Background The associations of social isolation and loneliness with premature mortality are
well known, but the risk factors linking them remain unclear. We sought to identify risk factors …

Objective To examine whether social isolation and loneliness (1) predict acute myocardial
infarction (AMI) and stroke among those with no history of AMI or stroke, (2) are related to …

We studied the developmental trends of temperament and character in a longitudinal
population-based sample of Finnish men and women aged 20–45 years using the Temperament …

Background: Depression and anxiety are leading causes of disability worldwide but often
remain undetected and untreated. Smartphone and wearable devices may offer a unique …

Extraversion is a relatively stable and heritable personality trait associated with numerous
psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic …

We examined whether personality traits are differently associated with coronary heart
disease and stroke mortality. Participants were pooled from three prospective cohort studies (…