Aberrant activation of innate immune pathways is associated with a variety of diseases.
Progress in understanding the molecular mechanisms of innate immune pathways has led to the …

The ideal fluorescent probe for bioimaging is bright, absorbs at long wavelengths and can
be implemented flexibly in living cells and in vivo. However, the design of synthetic …

We introduce far-red, fluorogenic probes that combine minimal cytotoxicity with excellent
brightness and photostability for fluorescence imaging of actin and tubulin in living cells. …

The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved
in multiple aspects of messenger RNA metabolism, including the repression of alternative …

… = (8πl B I) -1/2 , where I is the ionic strength of the solution and l B is the Bjerrum length, the
distance at which the electrostatic energy of the interaction between two elementary charges …

The Fox‐1 protein regulates alternative splicing of tissue‐specific exons by binding to
GCAUG elements. Here, we report the solution structure of the Fox‐1 RNA binding domain (RBD) …

Cell-permeable DNA stains are popular markers in live-cell imaging. Currently used DNA
stains for live-cell imaging are either toxic, require illumination with blue light or are not …

… with 24mm in man, which potentially allows for a large optical image (Reymond and Wolfe,
t98I). … light (Reymond and Wolfe, 1981). Reymond and Wolfe argued that the poor ~rforman~ …

We used single-molecule FRET in combination with other biophysical methods and molecular
simulations to investigate the effect of temperature on the dimensions of unfolded proteins…

Here we present a far-red, silicon-rhodamine-based fluorophore (SiR700) for live-cell multicolor
imaging. SiR700 has excitation and emission maxima at 690 and 715 nm, respectively. …