By ignoring the root causes of disease and neglecting to prioritize lifestyle measures for
prevention, the medical community is placing people at harm. Advanced nations, influenced by a …

Mammalian telomeres are thought to be composed of a tandem array of TTAGGG repeats. To
further define the type and arrangement of sequences at the ends of human chromosomes, …

We used cross-linking and immunoprecipitation coupled with high-throughput sequencing
to identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding …

Many metazoan gene transcripts exhibit neuron-specific splicing patterns, but the developmental
control of these splicing events is poorly understood. We show that the splicing of a …

FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved
in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We found that FUS/TLS …

Many alternative splicing events create RNAs with premature stop codons, suggesting that
alternative splicing coupled with nonsense-mediated decay (AS-NMD) may regulate gene …

Cultivated strawberry emerged from the hybridization of two wild octoploid species, both
descendants from the merger of four diploid progenitor species into a single nucleus more than …

Despite significant advances in prevention and treatment strategies, graft-versus-host disease
remains the most significant cause of morbidity and nonrelapse mortality after allogeneic …

Understanding how RNA binding proteins control the splicing code is fundamental to
human biology and disease. Here, we present a comprehensive study to elucidate how …

The Rbfox family of RNA binding proteins regulates alternative splicing of many important
neuronal transcripts, but its role in neuronal physiology is not clear 1 . We show here that …