We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

… After applying the HMM, at a focal SNP ℓ, each of the other haplotypes j therefore has some
probability \(p_{ij\ell }\) of being copied from, to generate haplotype i. After rescaling \(\log p_{…

The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and
they remained widespread throughout the last Ice Age when many other large mammal …

Background. Bone loss is an important problem in renal transplant recipients immediately
after surgery. No data are available about the bone loss beyond the first post-transplantation …

The Holocene (beginning around 12,000 years ago) encompassed some of the most significant
changes in human evolution, with far-reaching consequences for the dietary, physical …

We present a full-likelihood method to infer polygenic adaptation from DNA sequence variation
and GWAS summary statistics to quantify recent transient directional selection acting on …

… we denote by an indicator variable S ℓ i j (⁠ ℓ indexing SNPs). We multiply … ℓ ∏ i , j P S ℓ i
j a ℓ , θ ) ⁠, where θ denotes piecewise-constant coalescence rates and a ℓ is the age of the ℓ …

We assembled an ancestrally diverse collection of genome-wide association studies of type
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …

Ancient DNA is a valuable tool for investigating genetic and evolutionary history that can
also provide detailed profiles of the lives of ancient individuals. In this study, we develop a …

A key question in biology is why genomic variation persists in a population for extended
periods. Recent studies have identified examples of genomic deletions that have remained …