The monolayer of columnar epithelial cells lining the gastrointestinal tract—the intestinal
epithelial barrier (IEB)—is the largest exchange surface between the body and the external …

… NO, the most well-known vasodilator substance, is a reactive, gaseous molecule with a
half-life of 3–5 s, produced from l-arginine by one of the three NOS isoforms. These isoforms are …

… Author links open overlay panel Michel Neunlist 1 2 3 , Malvyne Rolli-Derkinderen 1 2 3 ,
Rocco Latorre 4 , Laurianne Van Landeghem 1 2 3 , Emmanuel Coron 1 2 3 , Pascal …

Mechanical forces influence many aspects of cell behaviour. Forces are detected and
transduced into biochemical signals by force-bearing molecular elements located at the cell …

Although recent studies have shown that enteric neurons control intestinal barrier function,
the role of enteric glial cells (EGCs) in this control remains unknown. Therefore, our goal was …

Recent identification of intestinal epithelial stem cell (ISC) markers and development of ISC
reporter mice permit visualization and isolation of regenerating ISCs after radiation to define …

… (vol/vol) heat-inactivated FBS, 2 mM l-glutamine, 0.1 mM nonessential amino acid (Invitrogen), …
L. Van Landeghem was supported by a grant French Ministry of Education Research and …

Nutrient intake regulates intestinal epithelial mass and crypt proliferation. Recent findings in
model organisms and rodents indicate nutrient restriction impacts intestinal stem cells (ISC). …

… We next plated cells on poly‐L‐Lysine‐coated surfaces to impede adhesion and perinuclear
actin filament formation, as demonstrated by their increased nuclear height (Fig EV2A and B…

Intestinal epithelial stem cells (IESCs) are critical to maintain intestinal epithelial function and
homeostasis. We tested the hypothesis that aging promotes IESC dysfunction using old (18-…