To the Editor—Rapid advances in DNA-sequencing and bioinformatics technologies in the
past two decades have substantially improved understanding of the microbial world. This …

The potential of the diverse chemistries present in natural products (NP) for biotechnology
and medicine remains untapped because NP databases are not searchable with raw data …

We present QIIME 2, an opensource microbiome data science platform accessible to users
spanning the microbiome research ecosystem, from scientists and engineers to clinicians …

Molecular networking has become a key method to visualize and annotate the chemical space
in non-targeted mass spectrometry data. We present feature-based molecular networking …

Innovation in mass spectrometry (MS) and the rapidly increasing throughput and sensitivity of
MS instrumentation require adaptations and innovations in data processing tools. Here, we …

Metabolomics using nontargeted tandem mass spectrometry can detect thousands of molecules
in a biological sample. However, structural molecule annotation is limited to structures …

Global Natural Product Social Molecular Networking (GNPS) is an interactive online small
molecule–focused tandem mass spectrometry (MS 2 ) data curation and analysis infrastructure…

Untargeted metabolomics experiments rely on spectral libraries for structure annotation, but,
typically, only a small fraction of spectra can be matched. Previous in silico methods search …

Despite advances in sequencing, lack of standardization makes comparisons across studies
challenging and hampers insights into the structure and function of microbial communities …

It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound(s) may not be isolated during …